理学部化学科

メニュー

佐々木　要／准教授

氏名

佐々木　要（Kaname Sasaki）

経歴

慶應義塾大学大学院理工学研究科基礎理工学専攻後期博士課程修了，博士（工学）取得
ウェイン州立大学（アメリカ合衆国ミシガン州デトロイト市）博士研究員
フランス国立科学研究センター天然物化学研究所（ICSN-CNRS，ジフ-シュル-イヴェット市）有期研究員
東北大学多元物質科学研究所生命機能分子合成化学研究分野助教
2013年４月より東邦大学理学部化学科講師経て，同准教授

専門分野

有機合成化学
糖質合成化学
ペプチド化学
核酸化学

主な研究課題

修飾タンパクの化学合成法の開発
高効率な糖鎖合成法の開発
核酸に作用する低分子の開発

主な研究業績

＜論文＞

Mhidia, R.; Boll, E.; Fècourt, F,Ermolenko, M.; Ollivier, N.; Sasaki,K.; Crich, D.; Delpech, B.; Melnyk, O. (2013)
Exploration Of An Imide Capture/N,N-Acyl Shift Sequence For Asparagine Native Peptide Bond Formation. Bioorg. Med. Chem., in press.
Aubry, S.; Sasaki, K.; Eloy, L.; Aubert, G.; Retailleau, P.; Cresteil, T.Crich, D. (2011)
Exploring the Potential of the β-Thiolactones in Bioorganic Chemistry. Org. Biomol. Chem., 2011, 9, 7134-7143.
Sasaki, K.Crich, D.(2011)
Facile Amide Bond Formation from Carboxylic Acids and Isocyanates Org. Lett., 2011, 12, 2256-2259.
Sasaki, K.Crich, D. (2010)
Cyclic Peptide Synthesis with Thioacids. Org. Lett., 2010, 11, 3254-3257.
Kusumi, S.; Sasaki, K.; Wang, S.; Watanabe, T.; Takahashi, D.; Toshima, K (2010)
Effective and chemoselective glycosylations using 2,3-unsaturated sugars. Org. Biomol. Chem., 2010, 3164-3178.
Kusumi, S.; Wang, S.; Watanabe, T.; Sasaki, K.; Takahashi, D.; Toshima, K (2010)
Chemoselective glycosylations using 2,3-unsaturated-4-keto glycosyl donors. Org. Biomol. Chem., 2010, 988-990.
Crich, D.; Sasaki, K (2009)
Reaction of thioacids with isocyanates and isothiocyanates: A convenient amide ligation process. Org. Lett., 2009, 11, 3514-3517.
Crich, D.; Sasaki, K.; Rahaman, M. Y.; Bowers, A. A. (2009)
One-pot syntheses of dissymmetric diamides based on the chemistry of cyclic monothioanhydrides. Scope and limitations and application to the synthesis of glycodipeptides. J. Org. Chem., 2009, 74, 3886-3893.

＜著書・総説＞

Sasaki, K.; Takahashi, D.; Toshima, K. (2012)
Ionic Liquids as Green Solvents for Glycosylation Reactions, In Green Solvents II. Properties and Applications of Ionic Liquids; Mohammad, A., Inamuddin, M. P., Eds.; Springer: Dordrecht, 2012, Chapter 3, pp. 67-78.
Sasaki, K.; Cumpstey, I.; Crich, D. (2011)
Radical Rearrangements: Ester-Substituted Radicals and Hydrogen Atom Migrations. In Encyclopedia of Radicals in Chemistry, Biology and Materials, Chatgilialoglu, C., Studer, A. Eds; Wiley, 2011, pp. 125-146.
Sasaki, K.; Aubry, S.; Crich, D. (2011)
Chemistry with and around thioacids. Phosphorus, Sulfur, and Silicon and the Related Elements, 2011, 186, 1005-1018.
Aubry, S.; Sasaki, K; Sharma, I.; Crich, D. (2011)
Influence of protecting groups on the reactivity and selectivity of glycosylation: Chemistry of the 4,6-O-benzylidene protected mannopyranosyl donors and related species. In Topics in Current Chemistry: Reactivity tuning in oligosaccharide assembly; Fraser-Reid, B., Cristobal-Lopez, J., Eds.; Springer: 2011, Vol. 301, pp. 141-188.
Sasaki, K. (2009)
Sodium methanethiosulfonate, In The Electronic-Encyclopedia of Reagents for Organic Synthesis, Wiley, 2009.