理学部生物分子科学科

メニュー

岸本利彦／教授

氏名

岸本利彦

経歴

昭和６２年３月　大阪大学工学部発酵工学科卒業
昭和６２年４月　大阪大学大学院工学研究科発酵工学専攻（博士課程前期）入学
平成元年３月　　同上修了
平成元年４月　　住友電気工業（株）入社　　バイオメディカル研究部（平成１３年２月まで）
平成９年９月　　博士（理学）取得（於：千葉大学）
平成１３年２月　住友電気工業（株）退社
平成１３年３月　東邦大学理学部着任　生物分子科学科（講師）
平成１８年４月　同上　助教授
平成１９年４月　同上　准教授
平成２６年４月　同上　教授　現在に至る

専門分野

細胞生物学
分子生物学
進化生物学

主な研究課題

適応・進化過程の分子生物学的・細胞生物学的解析

主な研究業績

＜論文＞

R. Wakai, M. Ishitsuka, T. Kishimoto, T. Ochiai, J. C. Nacher, Identification of genes and critical control proteins associated with inflammatory breast cancer using network controllability, PLoS One, 12, e0186353 (2017)
Y. Uchida, Y. Uchida, E. Shimoyama, N. Hiruta, T. Kishimoto, S. Watanabe, Human pericoronary adipose tissue as storage and possible supply site for oxidized low-density lipoprotein and high-density lipoprotein in coronary artery, Journal of Cardiology, 69, 1, 236-244, doi:10.1016/j.jjcc.2016.03.015 (2017)
Y. Uchida, Y. Uchida, E. Shimoyama, N. Hiruta, T. Kishimotoa, S. Watanabe, Human peri coronary adipose tissue as storage and possible supply site for oxidized low-density lipoprotein and high- density lipoprotein in coronary artery, Journal of Integrative Cardiology, 2, 6, 429-431, doi: 10.15761/JIC.1000192 (2016)
K. Terai, M. Jiang, W. Tokuyama, T. Murano, N. Takada, K. Fujimura, H. Ebinuma, T. Kishimoto, N. Hiruta, W. J. Schneider, H. Bujo, Levels of soluble LR11/SorLA are highly increased in the bile of patients with biliary tract and pancreatic cancers, Clinica Chimica Acta, 1, 457, 130-136 doi: 10.1016/j.cca.2016.04.010 (2016)
Y. Uchida, Y. Uchida, E. Shimoyama, N. Hiruta, T. Kishimoto, S. Watanabe, Pericoronary Adipose Tissue as Storage and Supply Site for Oxidized Low-Density Lipoprotein in Human Coronary Plaques, PLoS One, 11(3): e0150862. doi:10.1371 /journal.pone.0150862 (2016)
Ying Bei-Wen, Matsumoto Yuki, Kitahara Kazuki, Suzuki Shingo, Ono Naoaki, Furusawa Chikara, Kishimoto Toshihiko, Yomo Tetsuya, Bacterial transcriptome reorganization in thermal adaptive evolution, BMC Genomics, 16:802 DOI 10.1186/s12864-015-1999-x (2015)
T. Kishimoto, B.-W. Ying, S. Tsuru, L. Iijima, S. Suzuki, T. Hashimoto, A. Oyake, H. Kobayashi, Y. Someya, D. Narisawa, T. Yomo, Molecular clock of neutral mutations in a fitness-increasing evolutionary process, PLoS Genetics, 11(7), e1005392, DOI: 10.1371/ journal.pgen. 1005392 (2015)
M. Matsuo, T. Shimodaira, T. Kasama, Y. Hata, A. Echigo, M. Okabe, K. Arai, Y. Makino, S. Niwa, H. Saya, T. Kishimoto*, Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells, PLoS ONE, 8(11): e80392. doi:10.1371/journal.pone.0080392 (2013)
M. Matsuo, K. Terai, N. Kameda, A. Matsumoto, Y. Kurokawa, Y. Funase, K. Nishikawa, N. Sugaya, N. Hiruta, T. Kishimoto*, Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma, Biochem. Biophys. Res. Commun., 420, 901-906 (2012)
T. Kishimoto, L. Iijima, M. Tatsumi, N. Ono, A. Oyake, T. Hashimoto, M. Matsuo, M. Okubo, S. Suzuki, K. Mori, A. Kashiwagi, C. Furusawa, Bei-Wen Ying, T. Yomo, Transition from positive to neutral in mutation fixation along with continuing rising fitness in thermal adaptive evolution, PLoS Genetics, 6 (10), e1001164 (2010)
H. Yashiroda, T. Mizushima, K. Okamoto, T. Kameyama, H. Hayashi, T. Kishimoto, S. Niwa, M. Kasahara, E. Kurimoto, E. Sakata, K. Takagi, A. Suzuki, Y. Hirano, S. Murata, K. Kato, T. Yamane, K. Tanaka, Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S Proteasome, Nature structural & molecular biology, 15, 228-236 (2008)
S. Murata, K. Sasaki, T. Kishimoto, S. Niwa, H. Hayashi, Y. Takahama, K. Tanaka, Regulation of CD8+ T Cell Development by Thymus-Specific Proteasomes, Science, 316, 1349-1353 (2007)
Y. Hirano, H. Hayashi, S. Iemura, K. B. Hendil, S. Niwa, T. Kishimoto, M. Kasahara, T. Natsume, K. Tanaka, S. Murata, Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes, Mol. Cell, 24(6), 977-84 (2006)
S. Mimaki, Y. Mori-Furukawa, H. Katsuno, T. Kishimoto*, A transcriptional regulatory element screening system reveals a novel E2F1/pRb transcription regulation pathway, Anal. Biochem., 346, 268-280 (2005)
A. Tadokoro, H. Hayashi, T. Kishimoto, Y. Makino, S. Fujisaki, Y. Nishimura, Interaction of the Escherishia coli lipoprotein NipI with periplasmic Prc (Tsp) protease, J. Biochem (Tokyo), 135, 185-191 (2004)
Y. Makino, M. Kanemaki, A. Koga, K. Osano, T. Matsu-ura, Y. Kurokawa, T. Kishimoto, T. Tamura, Chromosome mapping nd expression of human tip49 family genes, DNA Seq., 11(1-2), 145-148 (2000)
K. Kokura, T. Kishimoto, T. Tamura, Identity between rat htf and human xbp-1 genes: determination of gene structure, target sequence, and transcription promotion function for HTF, Gene, 241, 297-307 (2000)
T. Takumi, Y. Nagamine, S. Miyake, C. Matsubara, K. Taguchi, S, Takekiba, Y. Sakakida, S. Yamaguchi, K. Yagita, K. Nishikawa, T. Kishimoto, S. Niwa, K. Okumura, H. Okamura, A mammalian homologue of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1, Genes Cells. 4, 67-75 (1999)
T. Nakadai, T. Kishimoto*, Y. Miyazawa, N. Okada, Y. Makino, T. Obinata, T. Tamura, HP33: hepatocellular carcinoma-enriched 33-kDa protein with similarity to Mitochondrial N-acyltransferase but localized in a microtubule-dependent manner at the centrosome, J. Cell Sci., 112,1353-1364 (1999) (*:equally contributed to first author)
T. Ohbayashi, Y. Makino, T. Kishimoto*, M. Shimada, T. Nakadai, T.Aoki, T. Kawata, S. Niwa, T. Tamura, Isolation of cDNA, chromosome mapping, and expression of the human TBP-like Protein (TLP), Biochem. Biophys. Res. Commun., 255, 137-149 (1999) (*: equally contributed to first author)
Y. Makino, T. Mimori, C. Koike, M. Kanemaki, Y. Kurokawa, S. Inoue, T. Kishimoto, T. Tamura, TIP49, Homologous to the Bacterial DNA Helicase RubB, acts as an autoantigen in Human, Biochem. Biophys. Res. Commun., 245, 817-823 (1998)
T. Nakadai, T. Kishimoto, K. Kokura, N. Ohkawa, Y. Makino, M. Muramatsu, T. Tamura, Cloning of A Novel rat gene, DB83, that encodes a putative membrane protein, DNA Research, 5, 315-317 (1998)
Y. Makino, K. Yamano, M. Kanemaki, T. Kishimoto, N. Shimbara, K. Tanaka, T. Tamura, SUG1, a component of the 26S proteasome, is an RNA-stimulated ATPase,　J. Biol. Chem. 272, 23201-23205 (1997)
M. Kanemaki, Y. Makino, T. Yoshida, T. Kishimoto, A. Koga, K. Yamamoto, M. Yamamoto, V. Moncollin, J.-M. Egly, M. Muramatsu, T. Tamura, Molecular cloning of a rat 49-kD TBP-interacting protein (TIP49) that is highly homologous to the bacterial RuvB, Biochem. Biophys. Res. Commun., 235, 64-68 (1997)
Y. Konishi, Y. Kobayashi, T. Kishimoto, Y. Makino, A. Miyawaki, T. Furuichi, K. Mikoshiba, T. Tamura, Demonstration of an E-box and its CNS-Related binding factors for transcriptional regulation of the mouse type 1 inositol 1,4,5-Triphosphate receptor gene, J. Neurochem. 69, 476-484 (1997)
T. Kishimoto, K. Kokura, N. Ohkawa, Y. Makino, M. Yoshida, S. Hirohashi, S. Niwa, M. Muramatsu, T. Tamura, Enhanced expression of a new class of liver-enriched B-Zip transcription factors, HTF, in hepatocellular carcinomas of rats and humans, Cell Growth & Diff., 9, 337-344 (1997)
S. Yogosawa, Y. Makino, T. Yoshida, T. Kishimoto, M. Muramatsu, T. Tamura, Molecular cloning of a nonel 120-kD TBP-interacting protein, Biochem. Biophys. Res. Commun., 229, 612-617 (1996)
Y. Makino, S. Yogosawa, M. Kanemaki, T. Yoshida, K. Yamano, T. Kishimoto, V. Moncollin, J-M. Egly, M. Muramatsu, T. Tamura, Structures of the rat proteasomal ATPases: Determination of highly conserved structural motifs and rules for their spacing, Biochem. Biophys. Res. Commun. 220, 1049-1054 (1996)
T. Ohbayashi, E. E. Schmidt, Y. Makino, T. Kishimoto, Y. Nabeshima, M. Muramatsu, T. Tamura, Promoter structure of the mouse TATA-Binding Protein (TBP) gene, Biochem. Biophys. Res. Commun. 225, 275-280 (1996)
T. Kishimoto, K. Kokura, T. Nakadai, Y. Miyazawa, T. Wakamatsu, Y. Makino, T. Nakamura, E. Hara, K. Oda, M. Muramatsu and T. Tamura, Overexpression of cysteine sulfinic acid decarboxylase stimulated by Hepatocarcinogenesis results in autoantibody production in rats, Cancer Res. 56, 5230-5237 (1996)
T. Kishimoto, K. Kokura, Y. Kumagai, Y. Makino and T. Tamura, HTF: A B-ZIP transcription factor that is closely related to the human XBP/TREB5 and is activated by hepatocellular carcinoma in rats, Biochem. Biophys. Res. Commun. 223, 746-751 (1996)
K. Kato, Y Makino, T. Kishimoto, J. Yamauchi, S. Kato, M. Muramatsu, T. Tamura, Multimerization of the mouse TATA-binding protein (TBP) driven by its C-terminal conserved domain, NucleicAcids Res., 22, 1179-1185 (1994)
K. Sumita, Y. Makino, K. Katoh, T. Kishimoto, M. Muramatsu, K. Mikoshiba, T. Tamura, Structure of a mammalian TBP (TATA-binding protein) gene: isolation of the mouse TBP genome, NucleicAcids Res., 21, 2769 (1993)
S. Hirose, M. Wakiya, Y. Kawano-Nishi, J. Yi, R. Sanokawa, S. Taki, T. Shimamura, T. Kishimoto, H. Tsurui, H. Nishimura, T. Shirai, Somatic diversification and affinity matuation of IgM and IgG anti-DNA antibodies in murine lupus, Eur. J. Immunol., 23, 11, 2813-2820 (1993)
T. Kishimoto, M. Itami, T. Yomo, I. Urabe, Y. Yamada and H. Okada, Improved methods for the preparation of N6-(2-carboxyethyl) NAD(H) and poly(ethyleneglycol) bound NAD(H), J. Fermentation and Bioengineering, 71, 447-449 (1991)

　(Proceeding)(査読あり)　　

H. Tsurui, T. Kishimoto, R. Sanokawa, T. Shirai, Precise discrimination among homologous sequences by DNA probe column chromatography, NucleicAcids Symposium Series, 25, 39-40 (1991)

＜英文総説＞

K. Kokura, T. Nakadai, T. Kishimoto, Y. Makino, M. Muramatsu, and T. Tamura Gene Expression in hepatoma (review article) J. Gastro. Hepto. 13, 132-141 (1998)

＜和文総説＞

田村隆明、牧野泰孝、岸本利彦　遺伝子発現の制御機構と転写研究の最近の進歩　日本臨床、53、 1033-1047, 1995
小池千加、牧野泰孝、岸本利彦、田村隆明　蛋白−蛋白の相互作用を利用した遺伝子クローニング（ピンポイントタグを利用したファーウエスタン法）　実験医学、14、87-93、1996
岸本利彦、古倉健嗣、田村隆明　肝臓癌の転写生物学、「転写因子研究の最前線'97」　実験医学、15、197-203、1997
牧野泰孝、小西慶幸、与五沢真吾、岸本利彦、田村隆明　Run-offAssay (in vitro 転写法)　臨床免疫、29、525-532、1997
岸本利彦　ヒストンアセチル化研究から見た転写研究の最近の動向　バイオミディア2000、9、401、2000
牧野泰孝、岸本利彦　クロマチン構造　分子細胞治療、3、2、161-165、2004
岸本利彦、四方哲也　実験室進化で探る変異率と進化の関係　バイオサイエンスとバイオインダストリー, 72, 4, 295-298, 2014

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