医学部

メニュー

びまん性肺疾患研究先端統合講座
(Department of Advanced and Integrated Interstitial Lung Diseases Research )

所属教員

本間 栄 教授(寄付講座)(責任者)
小山壱也 助教(寄付講座)
矢部マツ子 実験助手

研究の概要

 びまん性肺疾患の中でも近年、社会的注目度が極めて高い特発性肺線維症 (idiopathic pulmonary fibrosis; IPF)は、平均生存期間が3~5年といわれ極めて予後不良な難治性疾患で、国の指定難病の一つである。合併する肺癌や急性増悪、肺高血圧により死亡する例が多いため、基本的な治療法の確立と共に、この様な合併症に対する治療法の確立が喫緊の課題である。また、疾患多様性を有する間質性肺炎の診断は困難な場合が多く、高度の専門性が求められる。最終診断の精度を高めるには、間質性肺炎の診断に精通した臨床医、画像診断医、病理医による集学的検討 (multidisciplinary discussion; MDD)が重要であり、間質性肺炎が疑われた際は、できるだけ速やかに専門医に相談・紹介し、専門的な検査・診断・治療が必要である。しかしながら、我が国ではまだこのような系統的な専門施設や定期的にMDDを行える施設が殆どないのが現状であり、今後、MDD診断の普及と質の向上を目指して、他施設との連携を図りながら、各専門医を育成していくことが重要な課題の一つである。東邦大学大森医療センター呼吸器内科ではこの10年間で間質性肺炎の新規入院患者数、セカンドオピニオン外来患者数、臨床治験症例数、外科的肺生検症例、リハビリテーション導入症例、間質性肺炎合併肺癌手術症例ともに著増している。又、本間は厚生労働科学研究費補助金難治性疾患政策研究事業の「びまん性肺疾患に関する調査研究班」ならびに日本医療研究開発機構研究費難治性疾患実用化研究事業の「びまん性肺疾患に対するエビデンスを構築する新規戦略的研究班」の研究代表者(2014-2016年度)を歴任し、このような背景から各診療科・領域を統合した我が国の大学初の間質性肺炎センターを2017年4月開設し、当センターを拠点とした活動ならびに啓発活動を全国展開している。
 今回、2019年4月より医学部に寄付講座「びまん性肺疾患研究先端統合講座」を設置した。その研究内容は広く学際的なアプローチが必要な領域である。そのため、内科学講座呼吸器内科学分野(大森)のみならず大森病院呼吸器センター・間質性肺炎センター・リハビリテーション科・学外施設と連携し臨床研究ならびに若手医師の教育を推進するのみならず、本医学部の基礎講座・他大学とも連携し基礎研究を進める。東邦大学が我が国のびまん性肺疾患の診療・研究の拠点として更なる飛躍を遂げ、国民福祉に直接貢献できる寄付講座を目指す。以下に挙げる臨床研究・基礎研究に関する業務を継続する。
1.厚生労働科学研究費補助による班研究 分担研究者
  • 厚生労働科学研究費補助金難治性疾患政策研究事業「びまん性肺疾患に関する調査研究班」
  • 日本医療研究開発機構研究費難治性疾患実用化研究事業「びまん性肺疾患に対するエビデンスを構築する新規戦略的研究班」
  • 厚生労働科学研究費補助金難治性疾患等政策研究事業「難治性血管炎に関する調査研究班」
  • 日本医療研究開発機構(AMED)研究費(難治性疾患実用化研究事業)「特発性間質性肺炎の診断精度向上とエビデンス創出のためのクラウド型統合データベースとインタラクティブ診断システムの開発に関する研究班」
  • 日本医療研究開発機構(AMED)研究費(難治性疾患実用化研究事業)「難治性血管炎診療のエビデンス構築のための戦略的研究班」
2. 文部科学省平成28-31年度「私立大学研究ブランディング事業」選定事業 分担研究者
東邦大学研究ブランディング事業「上皮バリア機構の不全により生じる疾患の克服を目指したブランディング事業」
3. 日本呼吸器学会関連:特発性肺線維症の治療ガイドライン改訂
4. 慢性呼吸器疾患の疫学研究

関連研究課題

びまん性肺疾患関連
  • 在宅酸素療法導入後の間質性肺炎患者におけるバイタルサインの変動と入院リスクの検討
    間質性肺炎患者において細菌性肺炎や急性増悪といった呼吸器関連イベントの発生はQOLに関わるとともに時に致命的になる。本研究ではSpO2、呼吸回数や心拍数といったバイタルサインをモニタリングし、バイタルサインの変動から入院を要する呼吸器関連イベント発生リスクの予測を行うことが目的となる。これを明らかにする事は、バイタルサインは患者自身が注意を払う事ができる指標であるため呼吸器関連イベント発生時に早期受診を促し生命予後の改善に寄与する可能性がある。
  • 特発性肺線維症急性増悪におけるペリオスチンと成長因子のクロストークの解明
    特発性肺線維症急性増悪(IPF-AE)の病態を解明する足がかりとして、急性肺障害後の組織修復に関わるペリオスチンと、自然免疫系の誘導や炎症の惹起に関与する蛋白質であるHMGB1、線維化に関与する各種サイトカイン(TGF-β、MCP-1)や成長因子(PDGF,FGF,VEGF)等の血清、組織中の分布を検討し、IPF-AEにおける病態を明らかにし、治療ターゲットとなりうる分子の探索を行う。
  • 間質性肺疾患における治療標的分子の組織発現についての研究
    間質性肺炎は未だに病態不明の難治性疾患であり、有効な治療法は少ない。近年の研究から間質性肺炎増悪に関与する因子の解析が進んできており、いくつかの増悪因子が指摘されている。マウスのブレオマイシン肺線維症モデルにおける線維化の増悪に関して、ある特定の単球/マクロファージが線維化に関与していることが報告された。今後このような疾患特異的増悪因子の解析が進んでいくことが期待されるが、間質性肺炎は多様性を示す疾患であり、その表現型は特発性肺線維症から薬剤性肺障害に至るまで、きわめて多岐に渡る。さらに、ヒト検体を用いた上記のような特異的因子の解析報告は少ない。本研究において、間質性肺疾患における組織検体を免疫染色することで、特異的な治療標的因子や増悪因子を検索することができれば、新規の治療に結びつく可能性がある。
  • 特発性肺線維(IPF/UIP)のCT診断の標準化のための臨床画像病理データベースの作成
    “ATS-ERS-JRS新診断基準にもとづくIPF/UIPのCT診断の標準化”研究において、各施設でCRP診断されたUIP/IPFの画像所見、臨床経過、病理所見などを検討中であるが、これらのうち、適格症例かつ提供施設の了解の得られた症例について、臨床データ、画像、病理所見をデータベース化し、将来のUIP/IPFの画像、病理診断基準の標準化研究に資するとともに、画像所見の病理的背景を研究する。
  • サルコイドーシスにおける自然リンパ球, MAIT細胞の役割の検討
    サルコイドーシスは全身性肉芽腫性疾患であり本邦ではPropionibacterium acnesによる感染が一因とされる。また免疫学的機序が病態形成に関連し重要であるとされるが、自然免疫がどの程度その病態に寄与しているのかは不明である。Mucosal associated invariant T cells(MAIT細胞) は自然リンパ球の一種であり肉芽腫形成を促進するサイトカインの産生能が強く、病態形成に重要な働きを担っている可能性がある。自然リンパ球やMAIT細胞などの自然免疫系リンパ球に着目し、①その末梢血中の数や活性化状態、そこで得た結果と他のバイオマーカーとを比較しサルコイドーシスの病態への関与を解明すること、②組織へのMAIT細胞の浸潤を確認することを目的とする。また、③MAIT細胞のT細胞受容体を遺伝子導入したヒト細胞株を用いた解析により、MAIT細胞のサルコイドーシス病態形成への関与を検証する。
  • サルコイドーシスにおけるPAB抗体染色の有用性及び臨床的背景の検討
    サルコイドーシスは全身性の肉芽腫性疾患である。その正確な病因は未だ明らかではないが、サルコイドーシスの肉芽腫の病変部からPropionibacterium acnesが分離培養可能であり、Propionibacterium acnes感染がその発症要因として考えられるようになった。東京医科歯科大学の江石らのグループはPropionibacterium acnesの菌膜を構成するリポテイコ酸を抗原とするモノクローナル抗体(PAB抗体)を作成し、組織検体中のPropionibacterium acnesの局在を同定することに成功した。今回、PAB抗体による免疫染色を当院の症例に施行し、その有用性を検討する。
  • MPO-ANCA陽性間質性肺炎の国際協同コホート研究
    MPO-ANCA陽性間質性肺炎(IP)は全身性の血管炎に進展する症例と進展しない症例が存在する。そこで、MPO-ANCA陽性IP症例をMPAを発症する群(肺病変先行型MPA)としない群(肺限局型MPA疑)の2群に分け、それぞれの群について臨床的特徴・経過、バイオマーカー、原因遺伝子の解析、治療戦略を前向き、後ろ向きに集積し、国際的な地域差を検討する。
肺癌関連
  • 肺線維症合併肺癌における低酸素誘導性因子HIF-1α、VEGF等の発現の検討
    肺線維合併肺癌の発癌機序の一つとして、組織の低酸素状態の関与が着目されている。酸素供給が滞った低酸素組織内の細胞は低酸素誘導性因子(HIF)の活性化を介して、血管新生や解糖系エネルギー代謝亢進などのさまざまな遺伝子の発現を誘導し、環境への適応を図っている。これらHIFの中で、低酸素応答の中心的役割を担う因子はHIF-1αであることが知られている。HIF-1αの発現・活性化によりglucose transporter (GLUT) や血管内皮細胞増殖因子(VEGF)の発現が増加して解糖系エネルギー代謝や血管新生が促進される。また、細胞表面マーカーの一つであるCD13は低酸素状態および血管新生状態において発現の増幅がみられることも報告されている。
    本研究では、まだ解明されていないIPF合併肺癌における組織の低酸素曝露関連シグナル因子(HIF-1α、VEGF、GLUT、CD13、mTOR)の関与の有無を検証するため、IPF合併肺癌および非合併肺癌の手術検体を用いて腫瘍部と非腫瘍部、扁平上皮癌と腺癌で免疫染色を行い比較検討する。

代表的な業績

原著論文

  1. Homma S, Matsumoto T, Abe H, Fukuda Y, Nagano M, Suzuki M: Relapsing polychondritis - pathological and immunological findings in an autopsy case -. Acta Pathol Jpn (Pathol Int) 34: 1137-1146, 1984
  2. 本間 栄:膠原病肺の病理. 日胸疾会誌 23:332−347, 1985
  3. Morinari H, Terashi R, Okubo S, Homma S, Tanaka M: Remission of pulmonary alveolar proteinosis during antituberculosis chemotherapy. Eur J Resp Dis (Eur Respir J) 71: 54-55, 1987
  4. Homma S, Jones R, Qvint J, Zapol WM, Reid L: Pulmonary vascular lesions in the adult respiratory distress syndrome caused by inhalation of zinc chloride smoke. A morphometric study. Hum Pathol 23: 45-50, 1992
  5. Nagaoka I, Homma S, Someya A, Iwabuchi K, Yamashita T: Differential expression of the platelet-derived growth factor-A and -B genes during maturation of monocytes to macrophages. Comp Biochem Physiol 103B: 349-356, 1992
  6. Matsumoto T, Okada M, Kuwabara N, Homma S, Suzuki T, Kira S, Uekusa T, Saiki S: Polyarteritis nodosa and acute interstitial pneumonia. Ann Rheum Dis 51: 1344-1345, 1992
  7. Matsumoto T, Homma S, Okada M, Kuwabara N, Kira S, Hoshi T, Uekusa T, Saiki S: The lung in polyarteritis nodosa : A pathologic study of 10 cases. Hum Pathol 24: 717-724, 1993
  8. Homma S, Nagaoka I, Abe H, Takahashi K, Seyama K, Nukiwa T and Kira S: Localization of platelet-derived growth factor and insulin-like growth factor-I in the fibrotic lung. Am J Resp Crit Care Med 152: 2084-2089, 1995
  9. Takahashi K, Takahashi H, Maeda K, Homma S, Uekusa T, Dambara T, Kira S: An adult case of lymphangiomatosis of the mediastinum, pulmonary interstitium and retroperitoneum complicated by chronic disseminated intravascular coagulation. Eur Respir J 8: 1799-1802, 1995
  10. Homma S, Kawabata M, Kishi K, Tsuboi E, Narui K, Nakatani T, Uekusa T, Saiki S, Nakata K: Diffuse panbronchiolitis in rheumatoid arthritis. Eur Respir J 12: 444-452, 1998
  11. Homma S, Takimoto E, Kawabata M, Kishi K, Tsuboi E, Narui K, Nakatani T, Inagawa, Tateda K, Yamaguchi K, Nakata K: The first recognized patient with Legionella pneumophila serogroup 9 pneumonia in Japan. J infect chemother 4: 214-218, 1998
  12. Homma S, Kawabata M, Kishi K, Tsuboi E, Narui K, Nakatani T, Nakata K: Successful treatment of refractory bronchorrhea by inhaled indomethacin in two patients with bronchioloalveolar carcinoma. Chest 115: 1465-1468, 1999
  13. Homma S, Kawabata M, Kishi K, Tsuboi E, Narui K, Nakatani T, Saiki S, Nakata K: Bronchiolitis in Kartagener's syndrome. Eur Respir J 14: 1332-1339, 1999
  14. Homma S: Inhaled indomethacin in bronchorrhea in bronchioloalveolar carcinoma: Role of cyclooxygenase. Chest 117: 1213-1214, 2000
  15. Kishi K, Homma S, Tanimura S, Matsushita H, Nakata K: Hypoglycemia induced by secretion of high molecular weight insulin-like growth factor-II from a malignant solitary fibrous tumor of the pleura. Intern Med 40: 341-344, 2001
  16. Oki Y, Kami M, Kishi Y, Ueyama J, Homma S, Sugiyama T, Miyakoshi S, Kanda Y, Morinaga S, Muto Y: Pneumocystis carinii pneumonia with an atypical granulomatous response in a patient with chronic lymphocytic leukemia. Leuk Lymphoma 41: 435-438, 2001
  17. Kishi K, Homma S, Kawabata M,Tsuboi E, Narui K, Nakatani T, Nakata K: Pulmonary emboli caused by iliac compression syndrome without leg symptoms. Respiration 69: 269-272, 2002
  18. Kishi K, Homma S, Kurosaki A, Tanaka S, Matsushita H, Nakata K: Multiple atypical adenomatous hyperplasia with synchronous multiple primary bronchioloalveolar carcinomas. Intern Med 41: 474-477, 2002
  19. Homma S, Matsushita H, Nakata K: Pulmonary fibrosis in MPO-ANCA-associated vasculitides. Respirology 9: 190-196, 2004
  20. Kishi K, Homma S, Sakamoto S, Kawabata M,Tsuboi E, Nakata K, Yoshimura K: Efficacious pleurodesis with OK-432 and doxorubicin against malignant pleural effusions. Eur Respir J 24: 263-266, 2004
  21. Kishi K, Homma S, Kurosaki A, Motoi N, Kohno T, Nakata K, Yoshimura K: Small lung tumors with the size of 1 cm or less in diameter: clinical, radiological, and histopathological characteristics. Lung Cancer 44: 43-51, 2004
  22. Homma S, Miyamoto A, Sakamoto S, Kishi K, Motoi N, Yoshimura K: Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide. Eur Respir J 25: 200-204, 2005
  23. Homma S, Sakamoto S, Kawabata M, Kishi K, Tsuboi E, Motoi N, Yoshimura K: Cyclosporin treatment in coticosteroid-resistant and acutely exacerbated interstitial pneumonia. Intern Med 44: 1144-1150, 2005
  24. Kamio K, Matsushita I, Hijikata M, Tanaka G, Nakata K, Tokunaga K, Kobayashi Y, Taguchi Y, Homma S, Nakata K, Azuma A, Kudoh S, Keicho N: Promotor analysis and aberrant expression of MUC5B gene in diffuse panbronchiolitis. Am J Resp Crit Care Med 171: 949-957, 2005
  25. Kishi K, Homma S, Miyamoto A, Kurosaki A, Motoi N, Kohno T, Yoshimura K: Rounded atelectasis associated with pulmonary lymphangioleiomyomatosis. Intern Med 44: 625-627, 2005
  26. Homma S, Sakamoto S, Kawabata M, Kishi K, Tsuboi E, Hebisawa A, Motoi N, Yoshimura K: Comparative clinicopathology of obliterative bronchiolitis and diffuse panbronchiolitis. Respiration 73:481-487, 2006
  27. Kishi K, Homma S, Kurosaki A, Motoi N, Nakata K, Yoshimura K: High-Resolution Computed Tomography findings of lung cancer associated with idiopathic pulmonary fibrosis. J Comput Assist Tomogr 30: 95-99, 2006.
  28. Kishi K, Homma S, Kurosaki A, Kohno T, Motoi N, Yoshimura K: Clinical features and high-resolution CT findings of pulmonary cryptococcosis in non-AIDS patients. Resp Med 100: 807-812, 2006.
  29. Sekiya K, Sakai T, Homma S, Tojima H: Pulmonary tuberculosis accompanied by transient increase in serum carcinoembryonic antigen level with tuberculous empyema drainage. Intern Med 46: 1795-1798, 2007
  30. Izumikawa K, Ohtsu Y, Kawabata M, Takaya H, Miyamoto A, Sakamoto S, Kishi K, Tsuboi E, Homma S, Yoshimura K: Clinical efficacy of micafungin for chronic pulmonary aspergillosis. Med Mycol 45: 273-278, 2007
  31. Sekiya K, Hojo T, Yamada H, Toyama K, Ryo H, Kimura K, Taniguchi M, Homma S: Pneumoperitoneum recurring concomitantly with asthmatic exacerbation. Intern Med 47: 47-49, 2008
  32. Sugino K, Hasegawa C, Sano G, Shibuya K, Homma S: Pathophysiological study of chronic necrotizing pulmonary aspergillosis. Jap J Inf Dis 61: 450-453, 2008
  33. Sugino K, Kobayashi M, Iwata M, Gocho K, Kaburaki K, Muramatsu Y, Ishida F, Miyazaki T, Sato D, Sakaguchi M, Sano G, Kusano E, Isobe K, Sakamoto S, Takai Y, Shibuya K, Takagi K, Homma S: Successful treatment with pneumonectomy for pulmonary mycobacterium abscessus infection. Intern Med, 48:459-63, 2009
  34. Isobe K, Hata Y, Takai Y, Shibuya K, Takagi K, Homma S: Usefulness of fluoro-2-deoxyglucose positron emission tomography for investigating unexplained rising carcinoembryonic antigen levels that occur during the postoperative surveillance of lung cancer patients. Int J Clin Oncol 14: 497-501, 2009
  35. Sugino K, Kobayashi M, Sato D, Sakaguchi M, Sano G, Kusano E, Isobe K, Sakamoto S, Takai Y, Homma S: Marked improvement after long-term sildenafil therapy for secondary pulmonary arterial hypertension: A report of two cases. 東邦医会誌, 56:227-233, 2009
  36. Sekiya K, Sugino K, Hojo T, Ishida H, Sano G, Isobe K, Kimura K, Taniguchi M, Akiyama K, Homma S: Clinical evaluation of severe asthma attacks requiring tracheal intubation and mechanical ventilation. Allergol Int 58: 289-294, 2009
  37. Sugino K, Gocho K, Ota H, Kobayashi M, Sano G, Isobe K, Takai Y, Shibuya K, Izumi H, Kuraishi Y, Shibuya K, Homma S: Miliary tuberculosis associated with chronic neutrophilic leukemia. Intern Med, 48:1283-1287, 2009
  38. Sugino K, Kikuchi N, Kobayashi M, Muramatsu Y, Sano G, Kusano E, Isobe K, Sakamoto S, Takai Y, Hasegawa C, Shibuya K, Hatanaka K, Uekusa T, Homma S: A case of Churg-Strauss syndrome presenting with diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis. Intern Med, 48:1807-1811, 2009
  39. Sakamoto S, Homma S, Miyamoto A, Kurosaki A, Fujii T, Yoshimura K: Cyclosporin A treatment in acute exacerbation of idiopathic pulmonary fibrosis. Intern Med, 49:109-115, 2010
  40. Isobe K, Hata Y, Sakamoto S, Takai Y, Homma S: Clinical characterisitics of acute respiratory deterioration in pulmonary fibrosis associated with lung cancer following anti-cancer therapy. Respirology, 15:88-92, 2010
  41. Gocho K, Isobe K, Kaburaki K, Honda Y, Mitsuda A, Akasaka Y, Shimada N, Takagi K, Homma S: Malignant pleural mesothelioma presenting as an acute surgical abdomen due to metastatic jejunal perforation. Intern Med, 49:597-601, 2010
  42. Ito T, Sugino K, Satoh D, Muramatsu Y, Sano G, Sato K, Sakaguchi S, Isobe K, Sakamoto S, Takai Y, Hata Y, Shibuya K, Uekusa T, Kurosaki A, Homma S: Bird fancier’s lung which developed in a pigeon breeder presenting organizing pneumonia. Intern Med, 49:2605-0608, 2010
  43. Hata Y, Isobe K, Sasamoto S, Tamaki K, Takahasi S, Sato F, Mitsuda A, Okubo Y, Shibuya K, Homma S, Takagi K: Pulmonary hamartoma diagnosed by convex probe endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Intern Med, 49:1171-1173, 2010
  44. Tanaka N, Kusunoki Y, Kaneko K, Yamamoto T, Kaburaki M, Muraoka S, Abe H, Endo H, Sato D, Homma S, Shibuya K, Kawai S. Systemic lupus erythematosus complicated by recurrent pneumothorax: case report and literature review.Jpn J Clin Immunol (Nihon Rinsho Meneki Gakkai Kaishi) 33(3):162-168, 2010
  45. Inoue Y, Aizaki H, Hara H, Matsuda M, Ando T, Shimoji T, Murakami K, Masaki T, Shoji I, Homma S, Matsuura Y, Miyamura T, Wakita T, Suzuki T: Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein. Virology, 410: 38-47, 2011
  46. Sakamoto S, Homma S, Mun M, Fujii T, Kurosaki A, Yoshimura K: Acute exacerbation of idiopathic interstitial pneumonia following lung surgery in 3 of 68 consecutive patients: A retrospective study. Intern Med, 50:77-85, 2011
  47. Sugino K, Hebisawa A, Uekusa T, Hatanaka K, Abe H, Homma S: Histopathological bronchial reconstruction of human bronchiolitis obliterans. Pathol Intern, 61:192-201, 2011
  48. Isobe K, Hata Y, Sakguchi S, Sato K, Sano G, Sugino K, Sakamoto S, Takai Y, Shibuya K, Takagi K, Homma S: The role of fluoro-2-deoxyglucose positron emission tomography for the detection of gastrointestinal tract lesions in patients with lung cancer. Thoracic Cancer 2: 190-195, 2011
  49. Hijikata M, Matsushita I, Tanaka G, Tsuchiya T, Ito H, Tokunaga K, Ohashi J, Homma S, Kobashi Y, Taguchi Y, Azuma A, Kudoh S, Keicho N: Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis. Human Genetics, 129: 117-128, 2011
  50. Homma S, Azuma A, Taniguchi H, Ogura T, Mochiduki Y, Sugiyama Y, Nakata K, Yoshimura K, TakeuchiM, Kudoh S, the Japan NAC clinical study group: Efficacy of inhaled N-acetylcysteine monotherapy in patients with early stage idiopathic pulmonary fibrosis. Respirology17 : 467-477, 2012
  51. Takai Y, Yamashiro Y, Satoh D, Isobe K, Sakamoto S, Homma S: Cephalometric assessment of craniofacial morphology in Japanese male patients with obstructive sleep apnea–hypopnea syndrome. Sleep Biol Rhythms 10: 162–168, 2012
  52. Isobe K, Hata Y, Kobayashi K, Hirota N, Sato K, Sano G, Sugino K, Sakamoto S, Takai Y, Shibuya K, Takagi K, Homma S: Clinical significance of circulating tumor cells and free DNA in non-small cell lung cancer. Anticancer Res 32: 3339-3344, 2012
  53. Sakamoto S, Kikuchi N, Ichikawa A, Sano G, Satoh K, Sugino K, Takai Y, Shibuya K, Homma S: Everolimus-induced pneumonitis after drug-eluting stent implantation: a case report. CardioVasc Intervent Radiol DOI 10.1007/s00270-012-0477-y, 2012
  54. Isobe K, Hata Y, Sakaguchi S, Sato F, Takahashi S, Sato K, Sano G, Sugino K, Sakamoto S, Takai Y, Mitsuda A, Terahara A, Shibuya K, Takagi K, Homma S: Pathological response and prognosis of stage III non-small cell lung cancer patients treated with induction chemoradiation. Asia-Pac J Clin Oncol 8: 260-266, 2012
  55. Sugino K, Gocho K, Ishida F, Kikuchi N, Hirota N, Sato K, Sano G, Isobe K, Sakamoto S, Takai Y, Hata Y, Shibuya K, Uekusa T, Kurosaki A, Homma S: Acquired hemophilia A associated with IgG4-related lung disease in a patient with autoimmune pancreatitis. Intern Med 51: 3151-3154, 2012
  56. Hironori Uruga, Takeshi Fujii, Atsuko Kurosaki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa, Sakae Homma , Kazuma Kishi: Pulmonary tumor thrombotic microangiopathy: A clinical analysis of 30 sutopsy cases. Intern Med, 52:1317-1323, 2013
  57. Sugino K, Hebisawa A, Uekusa T, Hatanaka K, Abe H, Homma S: Bronchiolitis obliterans associated with Stevens-Johnson Syndrome: histopahological bronchial reconstruction of the whole lung and immunohistochemical study. Diag Pathol, 8:134-139, 2013
  58. Sugino K, Ota H, Fuaksawa Y, Uekusa T, Homma S: Pathological characteristics in idiopathic nonspecific interstitial pneumonia with emphysema and pulmonary hypertension. Respirology, 1:39-42, 2013
  59. Sakamoto S, Itoh T, Muramatsu Y, Sato K, Ishida F, Sugino K, Isobe K, Homma S: Efficacy of pirfenidone in patients with advanced-stage idiopathic pulmonary fibrosis. Intern Med 52: 2495-2501, 2013
  60. Sugino K, Uekusa T, Homma S: Granulomatous-lymphocytic interstitial lung disease in a patient with common variable immunodeficiency. Intern Med 52:2683-2684, 2013
  61. Okamoto T, Miyazaki Y, Ogura T, Chida K, Kohno N, Kohno S, Taniguchi H, Akagawa S, Mochizuki Y, Yamauchi K, Takahashi H, Johkoh T, Homma S, Kishi K, Ikushima S, Konno S, Mishima M, Ohta K, Nishioka Y, Yoshimura N, Munakata M, Watanabe K, Miyashita Y, Inase N: A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan. Respir Investig, 51: 191-199, 2013
  62. Sugino K, Ishida F, Kikuchi N, Hirota N, Sano G, Sato K, Isobe K, Sakamoto S, Takai Y, Homma S: Comparison of clinical characteristics and prognostic factors of combined pulmonary fibrosis and emphysema versus idiopathic pulmonary fibrosis alone. Respirology, 19:239-245, 2014
  63. Kazuya Koyama, Go Sano, Yoshinobu Hata, Nobuyuki Shiraga, Hiroki Ota,Keishi Sugino, Kazutoshi Isobe, Susumu Sakamoto, Yujiro Takai, Satoshi Koezuka,Takashi Makino, Hajime Otsuka, Fumitomo Sato, Shuichi Sasamoto, Akira Iyoda,Atsuko Kurosaki and Sakae Homma:An anomalous unilateral single pulmonary vein associatedwith a bone morphogenetic protein receptor II gene mutation. Intern Med 53: 461-466, 2014
  64. Muramatsu Y, Isobe K, Sugino K, Kinoshita A, Wada T, Sakamoto S, Takai Y, Sato F, Hata Y, Wakayama M, Sibuya K, Uekusa T, Iyoda A, Homma S. Malignant pleural mesothelioma mimicking the intrapulmonary growth pattern of epithelioid hemangioendothelioma. Pathol Int 64:358-60, 2014
  65. Isobe K, Hata Y, Tochigi N, Kaburaki K, Kobayashi H, Makino T, Otsuka H, Sato F, Ishida F, Kikuchi N, Hirota N, Sato K, Sano G, Sugino K, Sakamoto S, Takai Y, Shibuya K, Iyoda A, Homma S. Clinical significance of BIM deletion polymorphism in non-small-cell lung cancer with epidermal growth factor receptor mutation. J Thorac Oncol. 9(4): 483-7, 2014
  66. Yamamoto A, Sugino K, Kobayashi M, Hata Y, Homma S. Efficacy of nasal continuous positive airway pressure in tracheobronchomalacia. J Med Soc Toho. 61(4): 166-171, 2014
  67. Muramatsu Y, Isobe K, Sugino K, Kinoshita A, Wada T, Sakamoto S, Takai Y, Sato F, Hata Y, Wakayama M, Sibuya K, Uekusa T, Iyoda A, Homma S: Malignant pleural mesothelioma mimicking the intrapulmonary growth pattern of epithelioid hemangioendothelioma. Pathol Intern (Letter to the Editor), 64:358-360, 2014
  68. Hirota N, Ito T, Miyazaki S, Ebina M, Homma S: Gene expression profiling of lung myofibroblasts reveals the anti-fibrotic effects of cyclosporine. Tohoku J Exp Med, 233:283-293, 2014
  69. Takai Y, Yamashiro Y, Satoh D, Fukunaga S, Kobayashi M, Sugiyama K, Hatakeyama Y, Moriyama K, Komagamine M, Takasaki Y, Homma S: Association of obstructive sleep apnea syndrome with trapezius muscle hardness. J Med Soc Toho 61: 224-231, 2014
  70. Ganesh Raghu, Bram Rochwerg, Yuan Zhang, Carlos A. Cuello Garcia, Arata Azuma, Juergen Behr, Jan L. Brozek, Harold R. Collard, William Cunningham*, Sakae Homma, Takeshi Johkoh, Fernando J. Martinez, Jeffrey Myers, ShandraL.Protzko, LucaRicheldi, DavidRind, MoisesSelman, ArthurTheodore, AtholU.Wells, HenkHoogsteden, andHolgerJ.Schunemann;on behalf of theATS,ERS,JRS,andALAT. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis
An Update of the 2011 Clinical Practice Guideline. Am J Respir Crit Care Med 192: e3-e9, 2015
  71. Isobe K, Hata Y, Tochigi N, Kaburaki K, Kobayashi H, Makino T, Otsuka H, Ishida F, Hirota N, Sano G, Sugino K, Sakamoto S, Takai Y, Shibuya K, Iyoda A, Homma S. Usefulness of nanofluidic digital PCR arrays to quantify T790M mutation in EGFR-mutant lung adenocarcinoma. Cancer Genomics & Proteomics. 12: 31-38, 2015
  72. Sakamoto S, Muramatsu Y, Sato K, Ishida F, Kikuchi N, Sano G, Sugino K, Isobe K, Homma S: Effectiveness of combined therapy with pirfenidone and inhaled N-acetylcysteine for advanced idiopathic pulmonary fibrosis: A case-control study. Respirology, 20: 445-452, 2015
  73. Isshiki T, Sakamoto S, Kinoshita A, Sugino K, Kurosaki A, Homma S: Recombinant human soluble thrombomodulin treatment for acute exacerbation of idiopathic pulmonary fibrosis: A retrospective study. Respiration 89:201-207,2015 doi: 10.1159/000369828, 2015
  74. Bando M, Sugiyama Y, Azuma A, Ebina M, Taniguchi H, Taguchi Y, Takahashi H, Homma S, Nukiwa T, Kudoh S : A prospective survey of idiopathic interstitial pneumonias in a web registry in Japan . Respiratory Investigation, 53: 51-59, 2015
  75. Keishi Sugino, Yasuhiko Nakamura, Takafumi Ito, Takuma Isshiki, Susumu Sakamoto, Sakae Homma: Comparison of clinical characteristics and outcomes between combined pulmonary fibrosis and emphysema associated with usual interstitial pneumonia pattern and non-usual interstitial pneumonia. Sarcoidosis Vasc Diffuse Lung Dis, 32: 129-137, 2015
  76. Junya Tominaga, Fumikazu Sakai, Takeshi Johkoh, Satoshi Noma, Masanori Akira, Kiminori Fujimoto, Thomas V. Colby, Takashi Ogura, Yoshikazu Inoue,
 Hiroyuki Taniguchi, Sakae Homma, Yoshio Taguchi, Yukihiko Sugiyama : Diagnostic certainty of idiopathic pulmonary fibrosis/usual interstitial pneumonia: The effect of the integrated clinico-radiological assessment. European Journal of Radiology, 84 : 2640–2645, 2015
  77. Isshiki T, Sugino K, Gocho K, Furuya K, Shimizu M, Ohata T, Wada T, Isobe K, Sakamoto S, Takai Y, Homma S: Primary antiphospholipid syndrome associated with diffuse alveolar hemorrhage and pulmonary thromboembolism. Intern Med 54:2029-2033, 2015
  78. Kodama Y, Kishimoto Y, Muramatsu Y, Tatebe J, Yamamoto Y, Hirota N, Itoigawa Y, Atsuta R, Koike K, Sato T, Aizawa K, Takahashi K, Morita T, Homma S, Seyama K, Ishigami A: Antioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease (COPD), asthma-COPD overlap syndrome, and bronchial asthma, Clin Respir J, 2015Dec 14. doi: 10.1111/crj.12436.
  79. Saito T, Makino T, Hata Y, Koezuka S, Otsuka H, Isobe K, Tochigi N, Shibuya K, Homma S, Iyoda A.Giant thymoma successfully resected via3 anterolateral thoracotomy: a case report 
J Cardiothorac Surg. 2015 Sep 1;10:110
  80. Yoshinobu Hata, Hajime Otsuka, Takashi Makino, Satoshi Koezuka, Keishi Sugino, Nobuyuki Shiraga, Naobumi Tochigi, Kazutoshi Shibuya, Sakae Homma and Akira Iyoda :Surgical treatment of chronic pulmonary aspergillosis using preventive latissimus dorsi muscle flaps. Journal of Cardiothoracic Surgery 2015, 10:151 doi:10.1186/s13019-015-0354-2
  81. Keishi Sugino, Kyoko Gocho, Naoshi Kikuchi, Kazutoshi Shibuya,Toshimasa Uekusa, Sakae Homma: Acute exacerbation of combined pulmonary fibrosis and emphysema associated with Hermansky–Pudlak syndrome. Respirology Case Reports, 4: 13-15, 2016
  82. Muramatsu Y, Sugino K, Ishida F, Tatebe J, Morita T, Homma S: Effect of inhaled N-acetylcysteine monotherapy on lung function and redox balance in idiopathic pulmonary fibrosis. Respiratory Investigation 54:170-178, 2016
  83. Urabe N, Ishii Y, Hyodo Y, Aoki K, Yoshizawa S, Saga T, Murayama SY, Sakai K, Homma S, Tateda K: Molecular epidemiologic analysis of a Pneumocystis pneumonia outbreak among renal transplant patients. Clin Microbiol Infect 22:365-371, 2016
  84. Masashi Bando, Hiroyoshi Yamauchi, Takashi Ogura, Hiroyuki Taniguchi, Kentaro Watanabe, Arata Azuma, Sakae Homma and Yukihiko Sugiyama : Clinical experience of the long-term use of pirfenidone for idiopathic pulmonary fibrosis. Intern Med 55: 443-448, 2016
  85. Urabe N, Sakamoto S, Nakamura Y, Gocho K, Ishiwatari T, Homma S: Successful everolimus treatment of renal angiomyolipoma and lymphangioleiomyomatosis: A case report. Toho J Med 2 (1): 26-29, 2016.
  86. K. Sugino, Y Nakamura, Y Muramatsu, Y Hata, K Shibuya, S. Homma: Analysis of blood neutrophil elastase, glutathione levels and pathological findings in postoperative acute exacerbation of idiopathic pulmonary fibrosis associated with lung cance: Two case reports. MOLECULAR AND CLINICAL ONCOLOGY 5: 402-406, 2016
  87. OTSUKA H, SUGINO K, HATA Y, MAKINO T, KOEZUKA S, ISOBE K, TOCHIGI N, SHIBUYA K, Homma S, IYODA A : Clinical features and outcomes of patients with lung cancer as well as combined pulmonary fibrosis and emphysema . MOLECULAR AND CLINICAL ONCOLOGY 5: 273-278, 2016
  88. Sada KE, Harigai M, Amano K, Atsumi T, Fujimoto S, Yuzawa Y, Takasaki Y, Banno S, Sugihara T, Kobayashi M, Usui J, Yamagata K, Homma S, Dobashi H, Tsuboi N, Ishizu A, Sugiyama H, Okada Y, Arimura Y, Matsuo S, Makino H: Comparison of severity classification in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study. Mod Rheumatol. 2016 Mar 11:1-8.
  89. Kaori Watanabe-Imai, Masayoshi Harigai , Ken-ei Sada , Masahiro Yamamura , Takao Fujii , Hiroaki Dobashi , Koichi Amano, Satoshi Ito, Sakae Homma, Shunichi Kumagai, Shogo Banno, Yoshihiro Arimura, Hirofumi Makino, and For the Research Committee on Intractable Vasculitides, the Ministry of Health, Labor and Welfare of Japan 
: Clinical characteristics of and risk factors for serious infection in Japanese patients within six months of remission induction therapy for antineutrophil cytoplasmic antibody-associated vasculitis registered in a nationwide, prospective, inception cohort study. Mod Rheumatol, 2016; Early Online: 1–6.
  90. Shun Kondoh, Hirofumi Chiba, Hirotaka Nishikiori, Yasuaki Umeda, Koji Kuronuma, Mitsuo Otsuka,
Gen Yamada, Hirofumi Ohnishi, Mitsuru Mori, Yasuhiro Kondoh, Hiroyuki Taniguchi, Sakae Homma, Hiroki Takahashi: Validation of the Japanese disease severity classification and the GAP model in Japanese patients with idiopathic pulmonary fibrosis. Respiratory Investigation 54 (2016) 327–333
  91. Takahiro Yoshizawa, Keishi Sugino, Kazutoshi Shibuya, Toshimasa Uekusa Sakae Homma: Fibrocellular non-specific interstitial pneumonia with favourable prognosis in clinically amyopathic dermatomyositis
. Respirology Case Reports, 4 (5), 2016, e00180
  92. Go Sano,Tsutomu Itagaki, Naruhiko Ishiwada, Keita Matsubara,Satoshi Iwata, Yoshitaka Nakamori, Kenji Matsuyama,
Katsuya Watanabe, Yoshikazu Ishii, Sakae Homma and Kazuhiro Tateda : Characterization and evaluation of a novel immunochromatographic assay for pharyngeal Mycoplasma pneumoniae ribosomal protein L7/ L12 antigens. Journal of Medical Microbiology (2016), 65, 1–6
  93. Isobe K, Kakimoto A, Mikami T, Kaburaki K, Kobayashi H, Yoshizawa T, Makino T, Otusuka H, Sano G, Sugino K, Sakamoto S, Takai Y, Tochigi N, Iyoda A, Homma S: Association of BIM deletion polymorphism and BIM-γ RNA expression in NSCLC with EGFR mutation. CANCER GENOMICS & PROTEOMICS 13: 475-482 (2016)
  94. Ota H, SuginoK, uekusa T, Takemura T, Homma S: An autopsy case of refractory pulmonary hypertension with sarcoidosis. Respiratory Investigation 54: 490–493, 2016
  95. Kurosawa T, Sugino K, Isobe K, Hata Y, Fukasawa Y, Homma S: Primary malignant pericardial mesothelioma with increased serum mesothelin diagnosed by surgical pericardial resection: A case report. Molecular and Clinical Oncology 5: 553-556, 2016
  96. Azuma A, Taniguchi H, Inoue Y, Kondoh Y, Ogura T, Homma S, Fujimoto T, Sakamoto W, Sugiyama Y, Nukiwa T. Nintedanib in Japanese patients with idiopathic pulmonary fibrosis: A subgroup analysis of the INPULSIS® randomized trials. Respirology. 2016 Dec 20. doi: 10.1111/resp.12960
  97. Takashi Makino, Tetuo Mikami, Yoshinobu Hata, Hajime Otsuka, Satoshi Koezuka, Kazutohsi Isobe, Naobumei Tochigi, Kazutoshi Shibuya, Sakae Homma and Akira Iyoda : Comprehensive biomarkers for personalized treatment in pulmonary large cell neuroendocrine carcinoma: A comparative analysis with adenocarcinoma. Ann Thorac Surg 102:1694-1701, 2016
  98. Furuya K, Sakamot S, Takai Y, Sato N, Matsumoto K, Homma S. Acute exacerbation of idiopathic interstitial pneumonia after nonpulmonary surgery under general anesthesia: a retrospective study. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES 34: 156–164, 2017
  99. Miyamoto A, Kurosaki A, Fujii T, Kishi K, Homma S: HRCT features of surgically resected invasive mucinous adenocarcinoma associated with interstitial pnemonia. Respirology 22: 735-743, 2017
  100. Kaburaki K, Isobe K, Kobayashi H, Yoshizawa T, Takai Y, Homma S: A feasibility study of bevacizumab and vinorelbine in patients with previously treated advanced non-squamous non-small-cell lung cancer. Molecular and Clinical Oncology 6: 510-514, 2017
  101. Furuya K, Sakamoto S, Shimizu H, Sekiya M, Kinoshita A, Isshiki T, Sugino K, Matsumoto K, Homma S: Pirfenidone for acute exacerbation of idiopathic pulmonary fibrosis: A retrospective study. Respiratory Medicine 126: 93-99, 2017
  102. K. Sugino, M. Kobayashi, Y. Nakamura, K. Gocho, F. Ishida, K. Isobe, N. Shiraga, S. Homma: Xenon-enhanced dual-energy CT imaging in combined pulmonary fibrosis and emphysema. PLOS ONE 12(1): e0170289, 2017
  103. Akihiro Ishizu, Utano Tomaru, Sakiko Masuda, Ken-ei Sada, Koichi Amano, Masayoshi Harigai,
Yasushi Kawaguchi, Yoshihiro Arimura, Kunihiro Yamagata, Shoichi Ozaki, Hiroaki Dobashi, Sakae Homma, Yasunori Okada, Hitoshi Sugiyama, Joichi Usui, Naotake Tsuboi, Seiichi Matsuo, Hirofumi Makino and for the Research Committee of the Intractable Vasculitis Syndrome and the Research Committee of the Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan: Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis. Arthritis Research & Therapy (2017) 19:117 DOI 10.1186/s13075-017-1328-7
  104. Urabe N, Sakamoto S, Sano G, Suzuki J, Hebisawa A, Nakamura Y, Koyama K, Ishii Y, Tateda K, Homma S: Usefulness of two aspergillus PCR assays and β-D-glucan testing of bronchoalveolar lavage fluid for diagnosis of chronic pulmonary aspergillosis. J Clin Microbiol 55:1738-1746, 2017
  105. Kaburaki K, Sugino K, Kobayashi H, Sekiya T, Takai Y, Shibuya K, Homma S: Miliary tuberculosis that developed after intravesical bacillus calmet-guerin therapy. Inter Med 56: 1563-1567, 2017
  106. Yasuhiro Kondoh, Hiroyuki Taniguchi, Kensuke Kataoka, Taiki Furukawa, Masahiko Ando, Kenta Murotani, Michiaki Mishima, Yoshikazu Inoue, Takashi Ogura, Masashi Bando, Koichi Hagiwara, Takafumi Suda, Hirofumi Chiba, Hiroki Takahashi, Yukihiko Sugiyama, Sakae Homma: Disease severity staging system for idiopathic pulmonary fibrosis in Japan. Respirology. 2017 Nov;22(8):1609-1614.
  107. Kazuya Koyama, Susumu Sakamoto, Takuma Isshiki, Hiroshige Shimizu, Atsuko Kurosaki, Sakae Homma: The activities of daily living after an acute exacerbation of idiopathic pulmonary fibrosis. Intern Med Advance Publication) (DOI: 10.2169/internalmedicine.7875-16) 2017
  108. Sugino K, Nakamura Y, Sekiya M,Kobayashi H, Shibuya K, Homma S: Fatal diffuse alveolar haemorrhage mimicking acute exacerbation in idiopathic pulmonary fibrosis treated with nitedanib. Respirol Case Rep, 2017
  109. hunsuke Furuta, Afzal N. Chaudhry, Yoshihiro Arimura, Hiroaki Dobashi, Shouichi Fujimoto, Sakae Homma, Niels Rasmussen and David. Jayne : Comparison of the Phenotype and Outcome of Granulomatosis with Polyangiitis Between UK and Japanese Cohorts. J Rheumatol 44;216-222, 2017
  110. Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, Miyake S. Cutting edge: Anti-Tim-3 Treatment Exacerbates Pulmonary Inflammation and Fibrosis in Mice. J Immunol 199(11):3733-3737. 2017.
  111. Igarashi A, Iwanami Y, Sugino K, Gocho K, Homma S, Ebihara S: Using 6-min walk distance expressed as a percentage of reference to evaluate the effect of pulmonary rehabilitation in elderly patients with interstitial lung disease.J Cardiopulm Rehabl Prev 38:342-347, 2018
  112. Keishi Sugino, Hiroshige Shimizu, Yasuhiko Nakamura, Takuma Isshiki, Keiko Matsumoto, Sakae Homma : Clinico-radiological features and efficacy of anti-fibrotic agents in atypical idiopathic pulmonary fibrosis. J Thorac Dis 10;899-908, 2018
  113. Susumu Sakamoto, Hiroshige Shimizu, Takuma Isshiki, Keishi Sugino, Atsuko Kurosaki, Sakae Homma: Recombinant human soluble thrombomodulin for acute exacerbation of idiopathic pulmonary fibrosis: A historically controlled study Respiratory investigation 56 (2018) 136–143
  114. TAKASHI MAKINO, HAJIME OTSUKA, YOSHINOBU HATA, SATOSHI KOEZUKA, YOKO AZUMA, KAZUTOSHI ISOBE, KEISHI SUGINO, SATORU EBIHARA, Sakae Homma and AKIRA IYODA : Long‐acting muscarinic antagonist and long‐acting β2‐agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery. MOLECULAR AND CLINICAL ONCOLOGY 8: 647-652, 2018
  115. Kondoh Y, Taniguchi H, Kataoka K, Furukawa T, Shintani A, Fujisawa T, Suda T, Arita M, Baba T, Ichikado K, Inoue Y, Kishi K, Kishaba T, Nishiyama O, Ogura T, Tomii K, Homma S : Clinical spectrum and prognostic factors of possible UIP pattern on high-resolution CT in patients who underwent surgical lung biopsy. PLoS One. 2018 Mar 28;13(3):e0193608. doi: 10.1371/journal.pone.0193608. eCollection 2018.
  116. Nakamura Y, Sugino K, Kitani M, Hebisawa A, Tochigi N, Homma S: Clinico-radio-pathological characteristics of unclassifiable idiopathic interstitial pneumonias. Respiratory Investigation 56 : 40–47, 2018.
  117. Kazutoshi Isobe, Atsushi Kakimoto, Tetuo Mikami, Kyohei Kaburaki, Hiroshi Kobayashi, Takahiro Yoshizawa, Takashi Makino, Hajime Otsuka, Go Sano, Keishi Sugino, Susumu Sakamoto, Yujiro Takai, Naobumi Tochigi, Iyoda Akira, Sakae Homma :PD-L1 mRNA Expression in EGFR-mutant Lung Adenocarcinoma. Oncology Reports DOI: 10.3892/or.2018.6442, 2018
  118. Hiroshige Shimizu, Susumu Sakamoto, Takuma Isshiki, Kenta Furuya, Atsuko Kurosaki, Sakae Homma:Association of serum high-mobility group box protein 1 level with outcomes of acute exacerbation of idiopathic pulmonary fibrosis and fibrosing nonspecific interstitial pneumonia. PLoS ONE 13(5): e0196558., 2018
  119. Keishi Sugino, Takayuki Kabuki, Kazutoshi Shibuya, Sakae Homma : Systemic scleroderma-related interstitial pneumonia associated with borderline pulmonary hypertension. BML Case Rep 2018 doi:aa36/bcr-2017-221755
  120. Sakae Homma, Masashi Bando, Arata Azuma, Susumu Sakamoto, Keishi Sugino, Yoshiki Ishii, Shinyu Izumi, Naohiko Inase,
Yoshikazu Inoue, Masahito Ebina, Takashi Ogura, Kazuma Kishi, Tomoo Kishaba, Takashi Kido, Akihiko Gemma, Yoshihito Goto, Shinichi Sasaki, Takeshi Johkoh, Takafumi Suda, Kazuhisa Takahashi, Hiroki Takahashi, Yoshio Taguchi, Hiroshi Date, Hiroyuki Taniguchi, Takeo Nakayama, Yasuhiko Nishioka, Yoshinori Hasegawa, Noboru Hattori, Junya Fukuoka, Atsushi Miyamoto, Hiroshi Mukae, Akihito Yokoyama, Ichiro Yoshino, Kentaro Watanabe, on behalf of the Ministry of Health, Labour and Welfare, the Study Group on Diffuse Pulmonary Disorders, Scientific Research/Research on Intractable Diseases, and Japanese Respiratory Society : Japanese guideline for the treatment of idiopathic pulmonary fibrosis. Respiratory Investigation, 56:268-291, 2018.
  121. Igarashi A, Iwanami Y, Sugino K, Gocho K, Homma S, Ebihara S: Using 6-Min Walk Distance Expressed as a Percentage of Reference to Evaluate the Effect of Pulmonary Rehabilitation in Elderly Patients With Interstitial Lung Disease. J Cardiopulm Rehabil Prev. 2018 Feb 26. doi: 10.1097/HCR.0000000000000305
  122. Shion Miyoshi, Kazutoshi Isobe, Hiroshige Shimizu, Motoko Sunakawa, Aika Suzuki, Keishi Sugino, Nobuyuki Shiraga, Susumu Sakamoto, Yujiro Takai, Akira Iyoda, Sakae Homma: The Utility of Virtual Bronchoscopy Using
a Computed Tomography Workstation for Conducting Conventional Bronchoscopy:
A Retrospective Analysis of Clinical Practice. Respiration 2018 DOI: 10.1159/000492074
  123. Ohara S, Kanda S, Okuma H, Goto Y, Horinouchi H, Fujiwara Y, Nokihara H, Ito Y, Yamamoto N, Usui K, Homma S, Ohe Y: Effect of sequential chemoradiotherapy in patients with limited-disease small-cell lung cancer who were ineligible for concurrent therapy: a retrospective study at two institutions. Jpn J Clin Oncol. 2018 Jan 1;48(1):82-88. 124. Kazutoshi Isobe, Kyohei Kaburaki, Hiroshi Kobayashi, Go Sano, Susumu Sakamoto, Yujiro Takai, Naobumi Tochigi, Akira Iyoda, Sakae Homma:New risk scoring system for predicting acute exacerbation of interstitial pneumonia after chemotherapy for lung cancer associated with interstitial pneumonia. Lung Cancer 125:253-257, 2018
  124. Harigai M, Nagasaka K, Amano K, Bando M, Dobashi H, Kawakami T, Kishibe K, Murakawa Y, Usui J, Wada T, Tanaka E, Nango E, Nakayama T, Tsutsumino M, Yamagata K, Homma S, Arimua Y:2017 Clinical practice guidelines of the Japan Research Committee of the Ministry of Health, Labour and Welfare for Intractable Vasculitis for the management of ANCA-associated vasculitis. Mod Rheumatol 29:20-30, 2019
  125. Kazuya Koyama, Hisatsugu Goto, Shun Morizumi, Kozo Kagawa, Haruka Nishimura, Seidai Sato, Hiroshi Kawano, Yuko Toyoda, Hirohisa Ogawa, Sakae Homma, Yasuhiko Nishioka The Tyrosine Kinase Inhibitor TAS-115 Attenuates Bleomycin-Induced Lung Fibrosis in Mice. Am J Respir Cell Mol Biol. 2018 Dec 12. doi: 10.1165/rcmb.2018-0098OC. [Epub ahead of print]
  126. Kurosawa T, Miyoshi S, Yamazaki S, Nishina T, Mikami T, Oikawa A, Homma S, Nakano H: A murine model of acute lung injury identifies growth factors to promote tissue repair and their biomarkers. Genes Cells 24:112-125, 2019
  127. Kenji Nagasaka, Masayoshi Harigai, Noboru Hagino, Akinori Hara, Tetsuya Horita, Taichi Hayashi, Mitsuyo Itabashi, Satoshi Ito, Yasuhiro Katsumata, Soko Kawashima,Taio Naniwa, Ken-ei Sada, Eishu Nango, Takeo Nakayama, Michi Tsutsumino, Kunihiro Yamagata, Sakae Homma, Yoshihiro Arimura: Systematic Review and Meta-analysis for 2017 Clinical Practice Guidelines of the Japan Research Committee for Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare for the Management of ANCA-associated Vasculitis. Mod Rheumatol Jan;29(1):119-129. Doi, 2019
  128. Natsumi Namba, Aya Kawasaki, Ken-ei Sada, Fumio Hirano, 
Shigeto Kobayashi, Hidehiro Yamada, Hiroshi Furukawa, 
Kota Shimada, Atsushi Hashimoto,Toshihiro Matsui, Kenji Nagasaka, Takahiko Sugihara, Aika Suzuki, Kunihiro Yamagata,
Takayuki Sumida,Shigeto Tohma, Sakae Homma, Shoichi Ozaki, Hiroshi Hashimoto, Hirofumi Makino, Yoshihiro Arimura,
Masayoshi Harigai, Naoyuki Tsuchiya, On behalf of Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS) : Association of MUC5B promoter polymorphism with interstitial lung disease in myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis. Ann Rheum Dis 2019;0:1–2. doi:10.1136/annrheumdis-2018-214263
  129. Suzuki A, Sakamoto S, Kurosaki A, Kurihara Y, Satoh K, Usui Y, Nanki T, Arimura Y, Makino H, Okada Y, Harigai M, Yamagata K,1Sugiyama H, Dobashi H, Ishizu A, Tsuboi N, Usui J, Sada Ken-ei, Homma S: Chest high-resolution CT findings of microscopic polyangiitis: A Japanese first nationwide prospective cohort study. AJR 2019; 213:1–11
  130. Tomoyuki Fujisawa, Kazutaka Mori, Masashi Mikamo, Takashi Ohno, Kensuke Kataoka, Chikatoshi Sugimoto, Hideya Kitamura,
Noriyuki Enomoto, Ryoko Egashira, Hiromitsu Sumikawa, Tae Iwasawa, Shoichiro Matsushita, Hiroaki Sugiura, Mikiko Hashisako, Tomonori Tanaka, Yasuhiro Terasaki, Shinobu Kunugi, Masashi Kitani, Ryo Okuda, Yasuoki Horiike, Yasunori Enomoto, Hideki Yasui,
Hironao Hozumi, Yuzo Suzuki, Yutaro Nakamura, Junya Fukuoka, Takeshi Johkoh, Yasuhiro Kondoh, Takashi Ogura, Yoshikazu Inoue, Yoshinori Hasegawa, Naohiko Inase, Sakae Homma and Takafumi Suda: Nationwide cloud-based integrated database of idiopathic interstitial pneumonias for multidisciplinary discussion. Eur Respir J 2019; 53: 1802243

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