理学部生物分子科学科

メニュー

永田喜三郎/教授

氏名

永田喜三郎
永田喜三郎

経歴

  • 1991年3月東京理科大学薬学部薬学科卒業
  • 1991年4月東京大学大学院薬学研究科入学
  • 1993年3月同校 修士課程修了
  • 1996年3月同校 博士課程修了
  • 1996年4月東京都臨床医学総合研究所 免疫研究部門 研究員
  • 2003年12月東邦大学 理学部 生物分子科学科 講師 着任
  • 2008年4月東邦大学 理学部 生物分子科学科 准教授
  • 2017年4月東邦大学 理学部 生物分子科学科 教授

専門分野

免疫学
分子生物学
生化学

主な研究課題

  • 自然免疫応答における好中球の新たな役割の解明と老化との関わり

主な研究業績

<研究論文>
  1. Takahashi, R., Ishigami, A., Kobayashi Y., and Nagata, K.: Skewing of peritoneal resident macrophages toward M1-like is involved in enhancement of inflammatory responses induced by secondary necrotic neutrophils in aged mice.  Cellular Immunol. 304-305:44-48, 2016.
  2. Sekiguchi, S., Tomisawa, Y., Ohki, T., Tsuboi, K., Nagata, K., and Kobayashi, Y.: Suppression of macrophage-mediated phagocytosis of apoptotic cells by soluble b-glucan due to a failure of PKC-bII translaction. Int. Immunopharm. 31: 195-199, 2016.
  3. Takahashi, R., Totsuka, S., Ishigami, A., Kobayashi Y., and Nagata, K.: Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30knockout mice. Geriatr. Gerontol. Int. 16: 135-142, 2016.
  4. Suzuki, J., Hamada, E., Shodai, T., Kamoshida, G., Kudo, S., Itoh, S., Koike, J., Nagata, K., Irimura, T., and Tsuji, T.: Cytokine Secretion from human monocytes potentiated by P-selectin-mediated cell adhesion.  International archives of Allergy and immunology. 160: 152-160, 2013.
  5. Iwasa, T., Takahashi, R., Nagata, K., and Kobayashi, Y.: Suppression of MIP-2 production by annexin A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils. Biochemica et Biophysica Acta. 1822: 204-211, 2012.
  6. Yi, S., Kakinuma, S., Nishimura, M., Kobayashi, Y., Nagata, K.,and Shimada, Y.: Interleukin-9 Receptor Gene is Transcriptionally Regulated by Nucleolin in T-Cell Lymphoma Cells. Molecular Carcinogenesis. 51: 619-627, 2012.
  7. Sasaki, S., Tamaki, Y., Nagata, K., and Kobayashi, Y.: Regulation of the estrous cycle by neutrophils via opioid peptides.  J. Immunol. 187: 774-780, 2011.
  8. Nakayama, E., Shiratsuchi, Y., Kobayashi, Y., and Nagata, K.: The importance of infiltrating neutrophils in SDF-1 production leading to regeneration of the thymus after whole-body X-irradiation.   Cellular Immunol. 268: 24-28, 2011.
  9. Shibata, T., Nagata, K., and Kobayashi, Y.: Apoptotic neutrophils and nitric oxide regulate cytokine production by IFN-g-stimulated macrophages.  Cytokine 53: 191-195, 2011.
  10. Shibata, T., Nagata, K., and Kobayashi, Y.: The mechanism underlying the appearance of late apoptotic neutrophils and subsequent TNF-a production at a late stage during Staphylococcus aureus bioparticle-induced peritoneal inflammation in inducible NO synthase-deficient mice.  Biochemica et Biophysica Acta. 1802: 1105-1111, 2010.
  11. Sasaki, S., Nagata, K., and Kobayashi, Y.: Regulation of the estrous cycle by neutrophil infiltration into the vagina. Biochem. Biophys. Res. Commun. 382: 35-40, 2009.
  12. Terasawa, M.,Nagata, K., and Kobayashi, Y.: Neutrophils and monocytes transport tumor cell antigens from the peritoneal cavity to secondary lymphoid tissues. Biochem. Biophys. Res. Commun. 377: 589-594, 2008.
  13. Yamazaki, T., Nagata, K., and Kobayashi, Y.: Cytokine production by M-CSF- and GM-CSF-induced mouse bone marrow-derived macrophages upon coculturing with late apoptotic cells.  Cellular Immunol. 251: 124-130, 2008.
  14. Hatano, M., Sasaki, S., Ohata, S., Shiratsuchi, Y., Yamazaki, Y., Nagata, K., and Kobayashi, Y.: Effects of Kupffer cell-depletion on Concanavalin A-induced hepatitis.  Cellular Immunol. 251: 25-30, 2008.
  15. Fujiwara, H., Yamazaki, T., Uzawa, A., Nagata, K., and Kobayashi, Y.: Transient infiltration of neutrophils into the thymus following whole-body X-ray irradiation in IL-10 knockout mice. Biochem. Biophys. Res. Commun. 369: 432-436, 2008.
  16. Shibata, T., Nagata, K., and Kobayashi, Y.: Cutting Edge; A critical role of nitrogen oxide in preventing inflammation upon apoptotic cell clearance.  J. Immunol. 179: 3402-3406, 2007.
  17. Tanimoto, N., Terasawa, M., Nakamura, M., Kegai, D., Aoshima, N., Kobayashi Y., and Nagata, K.: Involvement of KC, MIP-2, and MCP-1 in leukocyte infiltration following injection of necrotic cells into the peritoneal cavity.  Biochem. Biophys. Res. Commun.361: 533-536, 2007.
  18. Itoh, S., Susuki, C., Takeshita, C., Nagata, K., and Tsuji, T.: Redistribution of P-selectin glycoprotein ligand-1 (PSGL-1) in chemokine-treated neutrophils: a role of lipid microdomains.  J. Leukoc. Biol.81: 1414-1421, 2007.
  19. Saijo, S., Nagata, K., Masuda, J., Matsumoto, I., and Kobayashi, Y.: Discrimination of early and late apoptotic cells by MDB-phosphatidylserine-labelling and time-lapse observation of phagocytosis of apoptotic cells by macrophages.  J. Biochem.141: 301-307, 2007.
  20. Shiratsuchi, Y., Iyoda, T., Tanimoto, N., Kegai D., Nagata, K., and Kobayashi, Y.: Infiltrating neutrophils induce allospecific CTL in response to immunization with apoptotic cells via MCP-1 production.  J. Leukoc. Biol.81: 412-420, 2007.
  21. Shibata, T., Nagata, K., and Kobayashi, Y.: Pivotal Advance; A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells.  J. Leukoc. Biol. 80: 744 752, 2006.
  22. Saijo, S., Nagata, K., Nakano, Y., Tobe, T. and Kobayashi, Y.: Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cells.  Biochem. Biophys. Res. Commun. 334: 1180-1183, 2005.
  23. Iyoda, T., Nagata, K., Akashi, M. and Kobayashi, Y.: Neutrophils accelerate macrophage-mediated digestion of apoptotic cells in vivo as well as in vitroJ. Immunol. 175: 3475-3483, 2005.
  24. Tsuchiya, K., Kawano, Y., Kojima, T., Nagata, K., Takao, T., Okada, M., Shinohara, H., Maki, K., Toyama-Sorimachi, N., Miyasaka, N., Watanabe, M., and Karasuyama, H.: Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS lett. 537: 203-209, 2003.
  25. Kouro, T., Nagata, K., Takaki, S., Karasuyama, H. and Takatsu, K.: Bruton's tyrosine kinase (Btk) is required for signaling the CD79b-mediated pro-B to pre-B cell transition. Int. Immunol. 13: 485-493, 2001.
  26. Kinoshita,T., Nagata, K., Sorimachi, N., Kayasuyama, H., Sekigucgi, T., Miyajima, A.: Oncostatin M Suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microeviroment.  Exp. Hemtol. 29: 1091-1097, 2001.
  27. Karasuyama, K., Tuganezawa, K., Kiyokawa, N., Matsuo, Y., Kitamura, F., Toyama-Sorimachi, N., Nagata, K., Kuida, K., and Fujimoto, J.: Expression profile of pre-B cell receptor components in acute lymphoblastic leukemia and its application to the diagnosis and classification of the disease. Tissue Antigens 55 (Supplement no.1): 20-21, 2000.
  28. Koike, J., Nagata, K., Kubo S., Tsuji, T., and Irimura T.: Density-dependent induction of TNF-a release from human monocytes by immobilized P-selectin.  FEBS lett. 477: 84-88, 2000.
  29. Nagata, K., Tsuji, T., Matsushima, K., Hanai, N. and Irimura, T.: Redistribution of selectin counter-ligands induced by cytokines. Int. Immunol. 12(4): 487-492, 2000.
  30. Maki, K., Nagata, K., Kitamura, F., Takemori, T. and Karasuyama, H.: Igb signaling regulates locus accessibility for ordered Ig gene rearrangements. J. Exp. Med. 191: 1333-1340, 2000.
  31. Endo, J., Toyama-Sorimachi, N., Taya, C., Kuramochi-Miyagawa, S., Nagata, K., Kuida, K., Takashi, T., Yonekawa, H., Yoshizawa, Y., Miyasaka, N. and Karasuyama, H.: Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. FEBS lett. 468: 234-238, 2000.
  32. 32.Nagata, K., Nakamura, T., Kitamura, F., Kuramochi, S., Taki, S., Campbell, K. S. and Karasuyama, H.: The Iga/Igb heterodimer on m-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity 7: 559-570, 1997.
  33. 33.Karasuyama, H., Nakamura, T., Nagata, K., Kuramochi, S., Kitamura, F. and Kuida, K.: The roles of preB cell receptor in early B cell development and its signal transduction. Immunol. Cell Biol. 75: 209-216, 1997.
  34. 34.Tsuji, T., Nagata, K., Koike, J., Todoroki, N., and Irimura, T.: Induction of superoxide anion production from monocytes and neutrophils by activated platelets through the P-selectin-sialyl Lewis X interaction.  J. Leukoc. Biol. 56: 583-587, 1994.
  35. 35.Nagata, K., Tsuji, T., Hanai, N., and Irimura,T.: Role of O-linked carbohydrate chains on leukocyte cell membranes in platelet-induced leukocyte activation.  J. Biol. Chem. 269: 23290-23295, 1994.
  36. 36.Nagata, K., Tsuji, T., Todoroki,N., Katagiri, Y., Tanoue, K., Yamazaki, H., Hanai,  N., and Irimura, T.: Activated platelets induced superoxide anion release by monocytes and neutrophils through P-selectin (CD62).  J. Immunol. 151: 3267-3273, 1993.
<研究総説>
  1. 永田喜三郎:プレB細胞レセプター. 免疫担当細胞上の細胞表面分子とその機能, 科学評論社, pp165-170, 科学評論社, 2000.
  2. 永田喜三郎、烏山 一:B細胞の初期分化.Annual Review 免疫, 1-13, 1999.
  3. 真木一茂、永田喜三郎、烏山 一:プレB細胞受容体による免疫グロブリン遺伝子再構成の制御.「臨床遺伝子学 ’99」最新医学9月増刊号     16-24, 1999.
  4. 永田喜三郎、烏山 一:プレB細胞レセプターの役割とシグナル伝達.臨床免疫, 30(5), 593-600, 1998.
  5. 永田喜三郎、烏山 一:B細胞の分化.アレルギー科, 4(5), 485-492, 1997.
  6. 永田喜三郎、辻 勉、入村達郎:「白血球膜表面糖鎖の役割:血小板/白血球接着反応によるスーパーオキシド産生」 細胞工学 15(10): 1435-1441, 1996.
  7. 永田喜三郎、辻 勉、入村 達郎:P?セレクチン/シアリルルイスX糖鎖相互作用を介した白血球の活性化. 臨床免疫, 27: 1050-1057,1995.
  8. 永田喜三郎、入村 達郎:セレクチン.医学のあゆみ, 169: 19-23, 1994.

主な担当科目

【大学科目】
  • 生化学I (Biochemistry I)
  • 遺伝子工学II (Genetic Engineering II)
  • 分子医学I~免疫が関わる疾患~ (Molecular Medicine~Immune-related disease)
  • 科学英語 (Scientific English)
  • 生理学・免疫学実習 (Practice in Physiology and Immunology)
【大学院科目】
  • 分子医学 (molecular Medicine)

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東邦大学 理学部

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千葉県船橋市三山2-2-1
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