医学部

メニュー

中野 裕康 / 教 授

略歴

1995 年 千葉大学大学院医学研究科博士過程修了
1995 年 順天堂大学医学部免疫学講座助手
2000~2003年 戦略的創造研究推進事業「さきがけ」PRESTO 研究員(兼任)
2001 年 順天堂大学大学院医学研究科免疫学講座講師
2007 年 順天堂大学大学院医学研究科免疫学講座准教授
2014 年 東邦大学医学部医学科生化学講座教授

学会活動等

日本免疫学会評議員, 日本生化学会代議員, 日本Cell Death学会評議員, 日本がん学会会員, 日本分子生物学会会員, American Society for Biochemistry and Molecular Biology 会員 日本免疫学会コミュニケーション委員会委員(2008年~2012年), 第3回免疫学会後援「免疫ふしぎ未来」実行委員長(2009年)

編集委員

  • Journal of Biological Chemistry (2007~2012年)
  • International Journal of Biochemistry and Molecular Biology
  • ISRN Oxidative Medicine
  • PLoS ONE

受賞など

1999年 いのはな同窓会学術賞(千葉大学医学部)
2001年 Human Frontier Science Program Young Investigators’ Grants Award
2008年 日本医師会医学研究奨励賞

学生募集

私達の教室はこの4月から中野の教授赴任に伴い研究テーマを一新してスタートしております。今後は医学部・薬学部・理学部・農学部・工学部など出身を問わず、熱意のある学生を受け入れたいと考えております。入学方法としては、医学部修士、医学系博士課程から受け入れます。私達の研究に興味を持たれた方は気軽にご相談ください。

連絡先

中野 裕康
E-mail: hiroyasu.nakanoの後ろに@med.toho-u.ac.jp
電話 03-3762-4151 内線2355, FAX 03-5493-5412

英文論文

  1. Nagashima, T., Okuyama, Y., Asao, A., Kawabe, T., Yamaki, S., Nakano, H., Croft, M., Ishii, N., and So, T. (2014) TNF receptor-associated factor 5 limits inflammatory CD4 T cell differentiation through antagonizing IL-6-receptor signaling. Nat Immunol in press.
  2. Wang, L., Lu, Y., Guan, H., Jiang, D., Guan, Y., Zhang, X., Nakano, H., Zhou, Y., Zhang, Y., Yang, L., and Li, H. (2013) Tumor Necrosis Factor Receptor Associated Factor 5 is an Essential Mediator of Ischemic Brain Infarction. J Neurochem 126, 400-414
  3. Speight, P., Nakano, H., Kelley, T. J., Hinz, B., and Kapus, A. (2013) Differential topical susceptibility to TGFbeta in intact and injured regions of the epithelium: key role in myofibroblast transition. Mol Biol Cell 24, 3326-3336
  4. Shindo, R., Kakehashi, H., Okumura, K., Kumagai, Y., and Nakano, H. (2013) Critical contribution of oxidative stress to TNFalpha-induced necroptosis downstream of RIPK1 activation. Biochem Biophys Res Commun 436, 212-216
  5. Ly, D. L., Waheed, F., Lodyga, M., Speight, P., Masszi, A., Nakano, H., Hersom, M., Pedersen, S. F., Szaszi, K., and Kapus, A. (2013) Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton. Am J Physiol Cell Physiol 304, C115-127
  6. Bian, Z., Dai, J., Nakano, H., Guan, H., Yuan, Y., Gan, L., Zhou, H., Zong, J., Zhang, Y., Li, F., Yan, L., Shen, D., Li, H., and Tang, Q. (2013) Disuption of Tumor Necrosis Factor Receptor Associated Factor 5 Exacerbates Pressure Overload Cardiac Hypertrophy and Fibrosis. J Cell Biochem 115, 349-358
  7. Ashida, H., Nakano, H., and Sasakawa, C. (2013) Shigella IpaH0722 E3 Ubiquitin Ligase Effector Targets TRAF2 to Inhibit PKC-NF-kappaB Activity in Invaded Epithelial Cells. PLoS Pathog 9, e1003409
  8. Piao, X., Komazawa-Sakon, S., Nishina, T., Koike, M., Piao, J. H., Ehlken, H., Kurihara, H., Hara, M., Van Rooijen, N., Schutz, G., Ohmuraya, M., Uchiyama, Y., Yagita, H., Okumura, K., He, Y. W., and Nakano, H. (2012) c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis. Sci Signal 5, ra93
  9. Piao, J. H., Yagita, H., Okumura, K., and Nakano, H. (2012) Aberrant accumulation of interleukin-10-secreting neutrophils in TRAF2-deficient mice. Immunol Cell Biol 90, 881-888
  10. Nishina, T., Komazawa-Sakon, S., Yanaka, S., Piao, X., Zheng, D. M., Piao, J. H., Kojima, Y., Yamashina, S., Sano, E., Putoczki, T., Doi, T., Ueno, T., Ezaki, J., Ushio, H., Ernst, M., Tsumoto, K., Okumura, K., and Nakano, H. (2012) Interleukin-11 links oxidative stress and compensatory proliferation. Sci Signal 5, ra5
  11. Minami, T., Kuwahara, K., Nakagawa, Y., Takaoka, M., Kinoshita, H., Nakao, K., Kuwabara, Y., Yamada, Y., Yamada, C., Shibata, J., Usami, S., Yasuno, S., Nishikimi, T., Ueshima, K., Sata, M., Nakano, H., Seno, T., Kawahito, Y., Sobue, K., Kimura, A., Nagai, R., and Nakao, K. (2012) Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice. EMBO J 31, 4428-4440
  12. Klionsky, D. J., et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8, 445-544
  13. Ushio, H., Ueno, T., Kojima, Y., Komatsu, M., Tanaka, S., Yamamoto, A., Ichimura, Y., Ezaki, J., Nishida, K., Komazawa-Sakon, S., Niyonsaba, F., Ishii, T., Yanagawa, T., Kominami, E., Ogawa, H., Okumura, K., and Nakano, H. (2011) Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol 127, 1267-1276 e1266
  14. Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S., Tanaka, K., Nakano, H., and Iwai, K. (2011) SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex. Nature 471, 633-636
  15. Piao, J. H., Hasegawa, M., Heissig, B., Hattori, K., Takeda, K., Iwakura, Y., Okumura, K., Inohara, N., and Nakano, H. (2011) Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2 Controls Homeostasis of the Colon to Prevent Spontaneous Development of Murine Inflammatory Bowel Disease. J Biol Chem 286, 17879-17888
  16. Nakano, H., and Ushio, H. (2011) An unexpected role for autophagy in degranulation of mast cells. Autophagy 7, 657-659
  17. Kojima, Y., Nakayama, M., Nishina, T., Nakano, H., Koyanagi, M., Takeda, K., Okumura, K., and Yagita, H. (2011) Importin beta1 Protein-mediated Nuclear Localization of Death Receptor 5 (DR5) Limits DR5/Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Cell Death of Human Tumor Cells. J Biol Chem 286, 43383-43393
  18. Charbonney, E., Speight, P., Masszi, A., Nakano, H., and Kapus, A. (2011) beta-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition. Mol Biol Cell 22, 4472-4485
  19. Missiou, A., Rudolf, P., Stachon, P., Wolf, D., Varo, N., Aichele, P., Colberg, C., Hoppe, N., Ernst, S., Munkel, C., Walter, C., Sommer, B., Hilgendorf, I., Nakano, H., Bode, C., and Zirlik, A. (2010) TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation. Circ Res 107, 757-766
  20. Masszi, A., Speight, P., Charbonney, E., Lodyga, M., Nakano, H., Szaszi, K., and Kapus, A. (2010) Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol 188, 383-399
  21. Ando, K., Hasegawa, K., Shindo, K., Furusawa, T., Fujino, T., Kikugawa, K., Nakano, H., Takeuchi, O., Akira, S., Akiyama, T., Gohda, J., Inoue, J., and Hayakawa, M. (2010) Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J 277, 2051-2066
  22. Tanaka, S., and Nakano, H. (2009) NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis. J Clin Invest 119, 2879-2881
  23. Kraus, Z. J., Nakano, H., and Bishop, G. A. (2009) TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40. Proc Natl Acad Sci U S A 106, 17140-17145
  24. Blackwell, K., Zhang, L., Thomas, G. S., Sun, S., Nakano, H., and Habelhah, H. (2009) TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. Mol Cell Biol 29, 303-314
  25. Sebe, A., Masszi, A., Zulys, M., Yeung, T., Speight, P., Rotstein, O. D., Nakano, H., Mucsi, I., Szaszi, K., and Kapus, A. (2008) Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor. FEBS Lett 582, 291-298
  26. Sawada, T., Nishiyama, C., Kishi, T., Sasazuki, T., Komazawa-Sakon, S., Xue, X., Piao, J. H., Ogata, H., Nakayama, J., Taki, T., Hayashi, Y., Watanabe, M., Yagita, H., Okumura, K., and Nakano, H. (2008) Fusion of OTT to BSAC Results in Aberrant Up-regulation of Transcriptional Activity. J Biol Chem 283, 26820-26828
  27. Nakajima, A., Kurihara, H., Yagita, H., Okumura, K., and Nakano, H. (2008) Mitochondrial Extrusion through the cytoplasmic vacuoles during cell death. J Biol Chem 283, 24128-24135
  28. Nakajima, A., Kojima, Y., Nakayama, M., Yagita, H., Okumura, K., and Nakano, H. (2008) Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells. Oncogene 27, 76-84
  29. Hasegawa, M., Fujimoto, Y., Lucas, P. C., Nakano, H., Fukase, K., Nunez, G., and Inohara, N. (2008) A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J 27, 373-383
  30. Zirlik, A., Bavendiek, U., Libby, P., MacFarlane, L., Gerdes, N., Jagielska, J., Ernst, S., Aikawa, M., Nakano, H., Tsitsikov, E., and Schonbeck, U. (2007) TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells. Arterioscler Thromb Vasc Biol 27, 1101-1107
  31. Sejas, D. P., Rani, R., Qiu, Y., Zhang, X., Fagerlie, S. R., Nakano, H., Williams, D. A., and Pang, Q. (2007) Inflammatory Reactive Oxygen Species-Mediated Hemopoietic Suppression in Fancc-Deficient Mice. J Immunol 178, 5277-5287
  32. Piao, J. H., Yoshida, H., Yeh, W. C., Doi, T., Xue, X., Yagita, H., Okumura, K., and Nakano, H. (2007) TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches. J Immunol 178, 2272-2277
  33. Mohan, S., Koyoma, K., Thangasamy, A., Nakano, H., Glickman, R. D., and Mohan, N. (2007) Low shear stress preferentially enhances IKK activity through selective sources of ROS for persistent activation of NF-kappaB in endothelial cells. Am J Physiol Cell Physiol 292, C362-371
  34. Fan, L., Sebe, A., Peterfi, Z., Masszi, A., Thirone, A. C., Rotstein, O. D., Nakano, H., McCulloch, C. A., Szaszi, K., Mucsi, I., and Kapus, A. (2007) Cell Contact-dependent Regulation of Epithelial-Myofibroblast Transition via the Rho-Rho Kinase-Phospho-Myosin Pathway. Mol Biol Cell 18, 1083-1097
  35. Wu, L., Nakano, H., and Wu, Z. (2006) The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1. J Biol Chem 281, 2162-2169
  36. Suzuki, S., Singhirunnusorn, P., Nakano, H., Doi, T., Saiki, I., and Sakurai, H. (2006) Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2. FEBS Lett 580, 3257-3262
  37. Nakano, H., Nakajima, A., Sakon-Komazawa, S., Piao, J. H., Xue, X., and Okumura, K. (2006) Reactive oxygen species mediate crosstalk between NF-kappaB and JNK. Cell Death Differ 13, 730-737
  38. Nakajima, A., Komazawa-Sakon, S., Takekawa, M., Sasazuki, T., Yeh, W. C., Yagita, H., Okumura, K., and Nakano, H. (2006) An antiapoptotic protein, c-FLIP(L), directly binds to MKK7 and inhibits the JNK pathway. EMBO J 25, 5549-5559
  39. Maeda, K., Nishiyama, C., Tokura, T., Nakano, H., Kanada, S., Nishiyama, M., Okumura, K., and Ogawa, H. (2006) FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice. Blood 108, 262-269
  40. Xue, X., Piao, J. H., Nakajima, A., Sakon-Komazawa, S., Kojima, Y., Mori, K., Yagita, H., Okumura, K., Harding, H., and Nakano, H. (2005) Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. J Biol Chem 280, 33917-33925
  41. Tabuchi, A., Estevez, M., Henderson, J. A., Marx, R., Shiota, J., Nakano, H., and Baraban, J. M. (2005) Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling. J Neurochem 94, 169-180
  42. Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J., and Ichijo, H. (2005) Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death. J Biol Chem 280, 37033-37040
  43. Nakano, H. (2005) A revival of old players. EMBO Rep 6, 126-127
  44. Kim, N., Kadono, Y., Takami, M., Lee, J., Lee, S. H., Okada, F., Kim, J. H., Kobayashi, T., Odgren, P. R., Nakano, H., Yeh, W. C., Lee, S. K., Lorenzo, J. A., and Choi, Y. (2005) Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med 202, 589-595
  45. Chen, L. F., Williams, S. A., Mu, Y., Nakano, H., Duerr, J. M., Buckbinder, L., and Greene, W. C. (2005) NF-{kappa}B RelA Phosphorylation Regulates RelA Acetylation. Mol Cell Biol 25, 7966-7975
  46. Yamada, T., Suzuki, M., Satoh, H., Kihara-Negishi, F., Nakano, H., and Oikawa, T. (2004) Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells. Exp Cell Res 294, 39-50
  47. So, T., Salek-Ardakani, S., Nakano, H., Ware, C. F., and Croft, M. (2004) TNF receptor-associated factor 5 limits the induction of Th2 immune responses. J Immunol 172, 4292-4297
  48. Sasazuki, T., Okazaki, T., Tada, K., Sakon-Komazawa, S., Katano, M., Tanaka, M., Yagita, H., Okumura, K., Tominaga, N., Hayashizaki, Y., Okazaki, Y., and Nakano, H. (2004) Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS. Mol Immunol 41, 547-551
  49. Nakano, H. (2004) Signaling crosstalk between NF-kappaB and JNK. Trends Immunol 25, 402-405
  50. Mattioli, I., Sebald, A., Bucher, C., Charles, R. P., Nakano, H., Doi, T., Kracht, M., and Schmitz, M. L. (2004) Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import. J Immunol 172, 6336-6344
  51. Hu, J., Nakano, H., Sakurai, H., and Colburn, N. H. (2004) Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells. Carcinogenesis 25, 1991-2003
  52. Gil, J., Garcia, M. A., Gomez-Puertas, P., Guerra, S., Rullas, J., Nakano, H., Alcami, J., and Esteban, M. (2004) TRAF family proteins link PKR with NF-kappa B activation. Mol Cell Biol 24, 4502-4512
  53. Sakurai, H., Suzuki, S., Kawasaki, N., Nakano, H., Okazaki, T., Chino, A., Doi, T., and Saiki, I. (2003) Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J Biol Chem 278, 36916-36923
  54. Sakon, S., Xue, X., Takekawa, M., Sasazuki, T., Okazaki, T., Kojima, Y., Piao, J. H., Yagita, H., Okumura, K., Doi, T., and Nakano, H. (2003) NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J 22, 3898-3909
  55. Saitoh, T., Nakayama, M., Nakano, H., Yagita, H., Yamamoto, N., and Yamaoka, S. (2003) TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation. J Biol Chem 278, 36005-36012
  56. Okazaki, T., Sakon, S., Sasazuki, T., Sakurai, H., Doi, T., Yagita, H., Okumura, K., and Nakano, H. (2003) Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses. Biochem Biophys Res Commun 300, 807-812
  57. Luftig, M., Prinarakis, E., Yasui, T., Tsichritzis, T., Cahir-McFarland, E., Inoue, J., Nakano, H., Mak, T. W., Yeh, W. C., Li, X., Akira, S., Suzuki, N., Suzuki, S., Mosialos, G., and Kieff, E. (2003) Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. Proc Natl Acad Sci U S A 100, 15595-15600
  58. Kanazawa, K., Azuma, Y., Nakano, H., and Kudo, A. (2003) TRAF5 functions in both RANKL- and TNFalpha-induced osteoclastogenesis. J Bone Miner Res 18, 443-450
  59. Hur, G. M., Lewis, J., Yang, Q., Lin, Y., Nakano, H., Nedospasov, S., and Liu, Z. G. (2003) The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation. Genes Dev 17, 873-882
  60. Chen, M. C., Hwang, M. J., Chou, Y. C., Chen, W. H., Cheng, G., Nakano, H., Luh, T. Y., Mai, S. C., and Hsieh, S. L. (2003) The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death. J Biol Chem 278, 16073-16081
  61. Sasazuki, T., Sawada, T., Sakon, S., Kitamura, T., Kishi, T., Okazaki, T., Katano, M., Tanaka, M., Watanabe, M., Yagita, H., Okumura, K., and Nakano, H. (2002) Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J Biol Chem 277, 28853-28860
  62. Saitoh, T., Nakano, H., Yamamoto, N., and Yamaoka, S. (2002) Lymphotoxin-beta receptor mediates NEMO-independent NF-kappaB activation. FEBS Lett 532, 45-51
  63. Nakayama, M., Ishidoh, K., Kayagaki, N., Kojima, Y., Yamaguchi, N., Nakano, H., Kominami, E., Okumura, K., and Yagita, H. (2002) Multiple pathways of TWEAK-induced cell death. J Immunol 168, 734-743
  64. Harada, N., Nakayama, M., Nakano, H., Fukuchi, Y., Yagita, H., and Okumura, K. (2002) Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells. Biochem Biophys Res Commun 299, 488-493
  65. Tada, K., Okazaki, T., Sakon, S., Kobarai, T., Kurosawa, K., Yamaoka, S., Hashimoto, H., Mak, T. W., Yagita, H., Okumura, K., Yeh, W. C., and Nakano, H. (2001) Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem 276, 36530-36534
  66. Seino, K., Setoguchi, Y., Ogino, T., Kayagaki, N., Akiba, H., Nakano, H., Taniguchi, H., Takada, Y., Yuzawa, K., Todoroki, T., Fukuchi, Y., Yagita, H., Okumura, K., and Fukao, K. (2001) Protection against Fas-mediated and tumor necrosis factor receptor 1-mediated liver injury by blockade of FADD without loss of nuclear factor-kappaB activation. Ann Surg 234, 681-688
  67. Okazaki, T., Nakao, A., Nakano, H., Takahashi, F., Takahashi, K., Shimozato, O., Takeda, K., Yagita, H., and Okumura, K. (2001) Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice. J Immunol 167, 1977-1981
  68. Matsushima, A., Kaisho, T., Rennert, P. D., Nakano, H., Kurosawa, K., Uchida, D., Takeda, K., Akira, S., and Matsumoto, M. (2001) Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. J Exp Med 193, 631-636
  69. Honda, K., Nakano, H., Yoshida, H., Nishikawa, S., Rennert, P., Ikuta, K., Tamechika, M., Yamaguchi, K., Fukumoto, T., Chiba, T., and Nishikawa, S. I. (2001) Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. J Exp Med 193, 621-630
  70. Sanz, L., Diaz-Meco, M. T., Nakano, H., and Moscat, J. (2000) The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J 19, 1576-1586
  71. Yamazaki, T., Hamano, Y., Tashiro, H., Itoh, K., Nakano, H., Miyatake, S., and Saito, T. (1999) CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells. J Biol Chem 274, 18173-18180
  72. Nakano, H., Sakon, S., Koseki, H., Takemori, T., Tada, K., Matsumoto, M., Munechika, E., Sakai, T., Shirasawa, T., Akiba, H., Kobata, T., Santee, S. M., Ware, C. F., Rennert, P. D., Taniguchi, M., Yagita, H., and Okumura, K. (1999) Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc Natl Acad Sci U S A 96, 9803-9808
  73. Morio, T., Hanissian, S. H., Bacharier, L. B., Teraoka, H., Nonoyama, S., Seki, M., Kondo, J., Nakano, H., Lee, S. K., Geha, R. S., and Yata, J. (1999) Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Immunity 11, 339-348
  74. Jin, D. Y., Giordano, V., Kibler, K. V., Nakano, H., and Jeang, K. T. (1999) Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma. J Biol Chem 274, 17402-17405
  75. Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoe, K., and Good, R. A. (1999) Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci U S A 96, 3859-3863
  76. Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., Nohara, C., Yagita, H., and Okumura, K. (1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J Immunol 162, 7058-7066
  77. Shindo, M., Nakano, H., Sakon, S., Yagita, H., Mihara, M., and Okumura, K. (1998) Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization. Cytogenet Cell Genet 82, 32-33
  78. Shindo, M., Nakano, H., Kuroyanagi, H., Shirasawa, T., Mihara, M., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., Yagita, H., and Okumura, K. (1998) cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. Biochem Biophys Res Commun 244, 285-292
  79. Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Muto, T., Yagita, H., and Okumura, K. (1998) Characterization of murine CD70 by molecular cloning and mAb. Int Immunol 10, 517-526
  80. Nishitoh, H., Saitoh, M., Mochida, Y., Takeda, K., Nakano, H., Rothe, M., Miyazono, K., and Ichijo, H. (1998) ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell 2, 389-395
  81. Nakano, H., Shindo, M., Sakon, S., Nishinaka, S., Mihara, M., Yagita, H., and Okumura, K. (1998) Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci U S A 95, 3537-3542
  82. Kashiwada, M., Shirakata, Y., Inoue, J. I., Nakano, H., Okazaki, K., Okumura, K., Yamamoto, T., Nagaoka, H., and Takemori, T. (1998) Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway. J Exp Med 187, 237-244
  83. Akiba, H., Nakano, H., Nishinaka, S., Shindo, M., Kobata, T., Atsuta, M., Morimoto, C., Ware, C. F., Malinin, N. L., Wallach, D., Yagita, H., and Okumura, K. (1998) CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. J Biol Chem 273, 13353-13358
  84. Nakano, H., Shindo, M., Yamada, K., Yoshida, M. C., Santee, S. M., Ware, C. F., Jenkins, N. A., Gilbert, D. J., Yagita, H., Copeland, N. C., and Okumura, K. (1997) Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32. Genomics 42, 26-32
  85. Aizawa, S., Nakano, H., Ishida, T., Horie, R., Nagai, M., Ito, K., Yagita, H., Okumura, K., Inoue, J., and Watanabe, T. (1997) Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. J Biol Chem 272, 2042-2045
  86. Nakano, H., Yamazaki, T., Miyatake, S., Nozaki, N., Kikuchi, A., and Saito, T. (1996) Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex. J Biol Chem 271, 6483-6489
  87. Nakano, H., Oshima, H., Chung, W., Williams-Abbott, L., Ware, C. F., Yagita, H., and Okumura, K. (1996) TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J Biol Chem 271, 14661-14664
  88. Nakata, K., Sugie, T., Cohen, H., Nakano, H., and Aoki, M. (1995) Expansion of circulating gamma delta T cells in active sarcoidosis closely correlates with defects in cellular immunity. Clin Immunol Immunopathol 74, 217-222
  89. Miyatake, S., Nakano, H., Park, S. Y., Yamazaki, T., Takase, K., Matsushime, H., Kato, A., and Saito, T. (1995) Induction of G1 arrest by down-regulation of cyclin D3 in T cell hybridomas. J Exp Med 182, 401-408
  90. Ohno, H., Goto, S., Taki, S., Shirasawa, T., Nakano, H., Miyatake, S., Aoe, T., Ishida, Y., Maeda, H., Shirai, T., Rajewsky, K., and Saito, T. (1994) Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand. EMBO J 13, 1157-1165
  91. Nakata, K., Sugie, T., Nakano, H., Sakai, T., and Aoki, M. (1994) Gamma-delta T cells in sarcoidosis. Correlation with clinical features. Am J Respir Crit Care Med 149, 981-988
  92. Nakano, H., Yamazaki, T., Ikeda, M., Masai, H., Miyatake, S., and Saito, T. (1994) Purification of glutathione S-transferase fusion proteins as a non-degraded form by using a protease-negative E. coli strain, AD202. Nucleic Acids Res 22, 543-544
  93. Nakano, H., Ohno, H., and Saito, T. (1994) Activation of phospholipase C-gamma 1 through transfected platelet-derived growth factor receptor enhances interleukin 2 production upon antigen stimulation in a T-cell line. Mol Cell Biol 14, 1213-1219
お問い合わせ先

東邦大学 医学部

〒143-8540
東京都大田区大森西 5-21-16
TEL:03-3762-4151